disease (di-zez´)

1. An interruption, cessation, or disorder of body functions, systems, or organs.illness, morbus, sickness; 2. A morbid entity characterized usually by at least two of these criteria: recognized etiologic agent(s), identifiable group of signs and symptoms, or consistent anatomical alterations. See also syndrome. 3. Literally, dis-ease, the opposite of ease, when something is wrong with a bodily function. [Eng. dis- priv. + ease]
aaa d. endemic anemia of ancient Egypt, ascribed in the Papyrus Ebers to intestinal infestation with ancylostoma; now called ancylostomiasis.
ABO hemolytic d. of the newborn erythroblastosis fetalis due to maternal-fetal incompatibility with respect to an antigen of the ABO blood group; the fetus possesses A or B antigen which is lacking in the mother, and the mother produces immune antibody which causes hemolysis of fetal erythrocytes.
accumulation d. a disease characterized by abnormal accumulation of a metabolic product in certain cells and tissues; examples include the mucopolysaccharidoses, lipoidoses.
Acosta's d. altitude sickness (1)
Adams-Stokes d. Adams-Stokes syndrome
adaptation d.'s d.'s falling theoretically into Selye's concept of the general-adaptation syndrome.
Addison-Biermer d. pernicious anemia
Addison's d. chronic adrenocortical insufficiency
Akabane d. a d. of cattle, sheep and goats, caused by the Akabane virus and characterized by fetal or neonatal arthrogryposis and hydranencephaly, abortions, and fetal death; the causative virus is transmitted by mosquitoes in Japan and by the midge Culicoides brevitarsis in Australia.
akamushi d. (ak-ka-mu´she) tsutsugamushi d
Akureyri d. epidemic neuromyasthenia
Albers-Schönberg d. osteopetrosis
Albert's d. achillobursitis involving inflammation of the bursa between the Achilles tendon and the os calcis.Swediauer's d;
Albright's d. McCune-Albright syndrome
Aleutian mink d. a chronic immune-complex d. of mink caused by a parvovirus.
Alexander's d. a rare, fatal central nervous system degenerative disease of infants, characterized by psychomotor retardation, seizures, and paralysis; megaloencephaly is associated with widespread leukodystrophic changes, especially in the frontal lobes.
alkali d. a term applied to various animal poisonings of plant and mineral origin in arid regions under the belief that they were caused by the ingestion of alkaline waters; e.g., botulism of wild ducks, caused by feeding on decayed vegetation in nearly dried-up lakes.
Almeida's d. paracoccidioidomycosis
Alpers d. poliodystrophia cerebri progressiva infantilis
altitude d. altitude sickness
Alzheimer's d. progressive mental deterioration manifested by loss of memory, ability to calculate, and visual-spatial orientation; confusion; disorientation. Begins in late middle life and results in death in 5-10 years. Pathologically, the brain is atrophic, especially in the frontal occipital and temporal regions; histologically, there is distortion of the intracellular neurofibrils (neurofibrillary tangles) and senile plaques composed of granular or filamentous argentophilic masses with an amyloid core, found predominantly in the cerebral cortex, amygdala, and hippocampus; the cerebral cortex has few and shrunken neurons which may contain cytoplasmic vacuoles and argentophilic granules displacing the nucleus to the periphery; the most common degenerative brain disorder.Alzheimer's dementia, presenile dementia (2) , dementia presenilis, primary neuronal degeneration, primary senile dementia; Alzheimer's accounts for some 60-70% of senile dementias, which in the U.S. afflict 5-10% of those over age 65, and 20% of those over age 80. In recent years, clinicians have instituted a protocol for monitoring the progress of the disease, known as FAST (functional assessment stages). Basic understanding of the brain changes brought about by Alzheimer's has been greatly aided by MRI and PET scanning; however, the cause of the disease is not yet clear. Arguments have been advanced for genetic, environmental, viral, neurochemical, and immunological causes. With the aging of the post-WW2 generation, the ranks of Alzheimer's patients are expected to swell, making the need for adequate diagnostic techniques and therapies more pressing. Treatments being explored include drugs to correct neurochemical imbalances. Some researchers are investigating repairing or augmenting damaged nerves through application of nerve growth factor or neural tissue transplants, but this approach remains highly experimental.
anarthritic rheumatoid d. rheumatoid d. without arthritis.
Anders' d. adiposis dolorosa
Andersen's d. type 4 glycogenosis
antibody deficiency d. antibody deficiency syndrome
aortoiliac occlusive d. obstruction of the abdominal aorta and its main branches by atherosclerosis.
Aran-Duchenne d. amyotrophic lateral sclerosis
Aujeszky's d. pseudorabies
Australian X d. Murray Valley encephalitis
autoimmune d. any disorder in which loss of function or destruction of normal tissue arises from humoral or cellular immune responses of the individual to his own tissue constituents; may be systemic, as systemic lupus erythematosus, or organ specific, as thyroiditis.
aviator's d. syndrome resembling decompression sickness occurring in occupants of airplanes that reach very high altitudes without adequate pressurization of the cabin. See also decompression sickness.
Ayerza's d. Ayerza's syndrome
Azorean d. Machado-Joseph
Baelz' d. cheilitis glandularis
Baló's d. encephalitis periaxialis concentrica
Baltic myoclonus d. one of the familial light sensitive myoclonic epilepsies. Unlike Lafora body polymyoclonus, where inclusion bodies are seen in the brain cells, the prognosis is often favorable. Probably an autosomal recessive disorder.
Bamberger-Marie d. hypertrophic pulmonary osteoarthropathy
Bamberger's d. 1. saltatory spasm 2. polyserositis
Bang's d. bovine brucellosis
Bannister's d. angioedema
Banti's d. Banti's syndrome
Barclay-Baron d. vallecular dysphagia
Barlow's d. infantile scurvy
Barraquer's d. progressive lipodystrophy
Basedow's d. Graves' d
Batten d. cerebral sphingolipidosis, late juvenile type.
Batten-Mayou d. cerebral sphingolipidosis, late infantile and juvenile types.
Bayle's d. paresis (2)
Bazin's d. erythema induratum
Bechterew's d. spondylitis deformans
Becker's d. an obscure South African cardiomyopathy leading to rapidly fatal congestive heart failure and idiopathic mural endomyocardial d.
Begbie's d. localized chorea.
Béguez César d. Chédiak-Steinbrinck-Higashi syndrome
Behçet's d. Behçet's syndrome
Behr's d. Behr's syndrome
Berger's d. focal glomerulonephritis
Bernard-Soulier d. (ber-nar´-sool-ya) an autosomal recessive disorder of absent or decreased platelet membrane glycoproteins Ib, IX, and V (the receptor for factor VIII R. This deficiency can lead to a failure to bind von Willebrand factor, causing moderate bleeding.
Bernhardt's d. meralgia paraesthetica
Besnier-Boeck-Schaumann d. sarcoidosis
Best's d. [MIM*153700] autosomal dominant retinal degeneration beginning during the first years of life. See also vitelliform degeneration.
Bielschowsky's d. early childhood type of lipofuscinosis.
Biermer's d. pernicious anemia
big liver d. See avian lymphomatosis.
Binswanger's d. one of the causes of multiinfarct dementia, in which there are many infarcts and lacunes in the white matter, with relative sparing of the cortex and basal ganglia.Binswanger's encephalopathy, encephalitis subcorticalis chronica, subcortical arteriosclerotic encephalopathy;
bird-breeder's d. bird-breeder's lung
black d. infectious necrotic hepatitis of sheep
black-tongue d. a d. of dogs similar to human pellagra and due to niacin deficiency.
blinding d. onchocerciasis
Bloch-Sulzberger d. incontinentia pigmenti
Blocq's d. astasia-abasia
Blount-Barber d. Blount's d
Blount's d. tibia vara; nonrachitic bowlegs in children.Blount-Barber d;
blue d. Rocky Mountain spotted fever
bluecomb d. of chickens an acute or subacute d. of young laying chickens characterized by lowered egg production, diarrhea, frequently cyanosis of the head, and pathologic changes involving chiefly the liver and kidney; etiology is not definitely established.avian monocytosis;
bluecomb d. of turkeys an acute or chronic d. of young turkeys caused by bluecomb virus, with diarrhea, loss of weight, and often cyanosis of the head.mud fever (2) , transmissible enteritis;
Boeck's d. sarcoidosis
border d. a congenital disorder of lambs caused by a pestivirus and characterized by low birth weight and viability, tremor, and an excessively hairy coat.hairy shaker d;
Borna d. an infectious encephalomyelitis of horses, cattle, and sheep caused by Borna disease virus and occurring in Germany and several other European countries; affected animals show depression, then excitement and spasms, and finally paralysis.enzootic encephalomyelitis; [Borna, Saxony where a severe epidemic occurred]
Bornholm d. epidemic pleurodynia [Bornholm, Danish island in the Baltic where the d. was first described]
Bosin's d. subacute sclerosing panencephalitis
Bouchard's d. myopathic dilation of the stomach.
Bouillaud's d. obsolete eponym for acute rheumatic fever with carditis.
Bourneville-Pringle d. facial lesions with tuberous sclerosis, first reported as adenoma sebaceum, but now recognized as angiofibromas.
Bourneville's d. tuberous sclerosis
Bowen's d. a form of intraepidermal carcinoma characterized by the development of pinkish or brownish papules covered with a thickened horny layer; microscopically, there is dyskeratosis with large round epidermal cells with large nuclei and pale-staining cytoplasm which are scattered through all levels of the epidermis.Bowen's precancerous dermatosis;
Brailsford-Morquio d. Morquio's syndrome
brancher glycogen storage d. type of glycogen storage d., due to deficiency of amylo-1,4-1,6-transglucosidase (brancher enzyme).brancher deficiency glycogenosis, debrancher deficiency;
Breda's d. espundia
Bright's d. nonsuppurative nephritis with albuminuria and edema, associated in fatal cases with large white kidneys; or with hematuria and red kidneys; or with contracted granular kidneys, corresponding to the stages of glomerulonephritis now termed subacute or membranous, acute, and chronic, respectively.
Brill's d. Brill-Zinsser d
Brill-Symmers d. obsolete term for nodular lymphoma.
Brill-Zinsser d. an endogenous reinfection associated with the "carrier state" in persons who previously had epidemic typhus fever; it is a rather mild d. and may be mistaken for endemic (murine) typhus; first described by Brill in New York City but not recognized as a recrudescent form of epidemic typhus until after the work of Zinsser.Brill's d., recrudescent typhus fever, recrudescent typhus;
Briquet's d. hysterical neurosis, conversion type.
brisket d. a d. of cattle, characterized by edematous swelling of the brisket and the tissues of the neck; the body cavities also contain large quantities of clear straw-colored transudate; this d. results from right heart failure as a consequence of increased pulmonary resistance, which is in some way associated with movement of animals to high altitudes.mountain sickness (2);
Brissaud's d. tic
broad beta d. type III familial hyperlipoproteinemia.
Brocq's d. a variety of parapsoriasis.
Brodie's d. 1. Brodie's knee 2. hysterical spinal neuralgia, simulating Pott's disease, following a trauma.
bronzed d. bronze diabetes See hemochromatosis.
Brooke's d. 1. trichoepithelioma; 2. keratosis follicularis contagiosa
Bruck's d. a d. marked by osteogenesis imperfecta, ankylosis of the joints, and muscular atrophy.
Brushfield-Wyatt d. a familial disorder characterized by unilateral nevus, contralateral hemiplegia, hemianopia, cerebral angioma, and mental retardation; possibly a variant of Sturge-Weber syndrome.nevoid amentia;
Buerger's d. thromboangiitis obliterans
bulging eye d. gedoelstiosis
Bürger-Grütz d. obsolete term for idiopathic hyperlipemia.
Bury's d. erythema elevatum diutinum
Buschke's d. 1. scleredema adultorum 2. obsolete eponym for cryptococcosis.
Busquet's d. an osteoperiostitis of the metatarsal bones, leading to exostoses on the dorsum of the foot.
Buss d. bovine sporadic encephalomyelitis
Busse-Buschke d. cryptococcosis
Byler d. [MIM*211600] familial intrahepatic cholestasis, with early onset of loose, foul-smelling stools, jaundice, hepatosplenomegaly, and dwarfism, due to an error in conjugated bile salt metabolism; autosomal recessive inheritance. [Byler, an Amish kindred]
Caffey's d. infantile cortical hyperostosis
caisson d. (ka´son) decompression sickness [Fr. caisson (fr. caisse, a chest) a water-tight box or cylinder containing air under high pressure used in sinking structural pilings underwater]
calcium pyrophosphate deposition d. (CPPD) a crystal deposition arthritis that may simulate gout.
Calvé-Perthes d. Legg-Calvé-Perthes d
Canavan's d. autosomal recessive degenerative d. of infancy; mostly in Jewish infants; onset typically within first 3-4 months of birth, consisting of blindness, psychomotor regression, enlarged head, optic atrophy, hypotonia, spasticity, increased N-acetylaspartic acid urinary excretion. MRI shows enlarged brain, decreased attenuation of cerebral and cerebellar white matter, and normal ventricles. Pathologically, there is increased brain volume and weight, and spongy degeneration in the subcortical white matter. See also leukodystrophy.Canavan's sclerosis, Canavan-van Bogaert-Bertrand d., spongy degeneration of infancy;
Canavan-van Bogaert-Bertrand d. Canavan's d
canine parvovirus d. an acute d. of dogs with a variable mortality rate caused by the canine parvovirus; seen in three distinct clinical forms; a generalized neonatal d., a severe nonsuppurative myocarditis, and a frequently fatal enteritis.
Caroli's d. [MIM*263200] congenital cystic dilation of the intrahepatic bile ducts, sometimes associated with intrahepatic stones and biliary obstruction; a part of the phenotype of infantile polycystic kidney.
Carrington's d. chronic eosinophilic pneumonia
Carrión's d. Oroya fever
Castleman's d. benign giant lymph node hyperplasia
cat-bite d. rat-bite fever, presumably spread from rats to cats and thus to humans.cat-bite fever;
cat-scratch d. a chronic benign adenopathy, especially in children and young adults, commonly associated with a recent cat scratch or bite and caused by bacteria including Rochalimaea henselae and Alipia felis; the lymphadenopathy usually resolves spontaneously within a period of several months, but complications involving central nervous system, liver, spleen, lung, and skin have been seen.benign inoculation lymphoreticulosis, benign inoculation reticulosis, cat-scratch fever, regional granulomatous lymphadenitis;
celiac d. a disease occurring in children and adults characterized by sensitivity to gluten, with chronic inflammation and atrophy of the mucosa of the upper small intestine; manifestations include diarrhea, malabsorption, steatorrhea, and nutritional and vitamin deficiencies.celiac sprue, celiac syndrome, gluten enteropathy;
central core d. [MIM*117000] a congenital myopathy characterized by hypotonia, delay of motor development in infancy, and nonprogressive or slowly progressive muscle weakness; on biopsy the central core of muscle fibers stains abnormally, myofibrils are abnormally compact, and there is virtual absence of mitochondria and sarcoplasmic reticulum; histochemically, the cores are devoid of oxidative enzyme, phosphorylase, and ATPase activity; autosomal dominant inheritance, often subclinical.
central Recklinghausen's disease type II type 1 neurofibromatosis. See neurofibromatosis.
cerebrovascular d. general term for a brain dysfunction caused by an abnormality of the cerebral blood supply.
Chagas' d. South American trypanosomiasis
Chagas-Cruz d. South American trypanosomiasis
a chain d. a vague or indefinite term; could be used for a-heavy-chain d. (a lymphoplasma cell proliferative d. usually seen in Mediterranean men, characterized by intestinal involvement with steatorrhea, often progressive with fatal outcome) or a thalassemia (a genetic abnormality in the alpha globin chain of hemoglobin).
Charcot-Marie-Tooth d. peroneal muscular atrophy
Charcot's d. amyotrophic lateral sclerosis
Charlouis' d. yaws
Cheadle's d. infantile scurvy
Chédiak-Higashi d. Chédiak-Steinbrinck-Higashi syndrome
Chiari's d. Chiari's syndrome
Chicago d. obsolete term for North American blastomycosis.
cholesterol ester storage d. [MIM*278000] a lipidosis caused by a deficiency of lysosomal acid lipase activity resulting in widespread accumulation of cholesterol esters and triglycerides in viscera with xanthomatosis, adrenal calcification, hepatosplenomegaly, foam cells in bone marrow and other tissues, and vacuolated lymphocytes in peripheral blood; autosomal recessive inheritance.
Christensen-Krabbe d. poliodystrophia cerebri progressiva infantilis
Christian's d. 1. Hand-Schüller-Christian d 2. relapsing febrile nodular nonsuppurative panniculitis
Christmas d. hemophilia B
chronic active liver d. chronic hepatitis
chronic granulomatous d. a congenital defect in the killing of phagocytosed bacteria by polymorphonuclear leukocytes, which cannot increase their oxygen metabolism either because of defective cytochrome [MIM*233710 and MIM*233690] or other specific factor deficiencies [MIM*233700 and MIM*306400]. As a result there is an increased susceptibility to severe infection; inheritance is usually autosomal recessive or X-linked.congenital dysphagocytosis, granulomatous d;
chronic hypertensive d. the chronic accumulative effects of long-standing high blood pressure on such vital organs as the heart, kidney, and brain.
chronic obstructive pulmonary d. (COPD) general term used for those diseases with permanent or temporary narrowing of small bronchi, in which forced expiratory flow is slowed, especially when no etiologic or other more specific term can be applied.
chronic respiratory d. (CRD) a common and serious d. of the respiratory tract of chickens caused by the bacterium Mycoplasma gallinarum; secondary infection with Escherichia coli is common.
chylomicron retention d. an inherited disorder in which apolipoprotein B-48 is retained in intestine and absent in plasma; results in fat malabsorption.
circling d. listeriosis in sheep.
Civatte's d. poikiloderma of Civatte
clover d. trifoliosis
Coats' d. exudative retinitis
Cockayne's d. Cockayne's syndrome
cold hemagglutinin d. a condition associated with the presence of hemagglutinating autoantibody active in vivo but in vitro particularly or solely active in the cold; when the concentration of IgM antibody is high there may be increased serum viscosity, but clinical manifestations (due to hemagglutination) usually appear following exposure to cold; hemolysis usually is mild but may be severe, resulting in autoimmune hemolytic anemia, cold antibody type.
collagen d.'s , collagen-vascular d.'s a group of generalized d.'s affecting connective tissue and frequently characterized by fibrinoid necrosis or vasculitis; in some collagen d.'s, auto-immunization, particularly antinuclear antibodies, has been shown and circulating immune complexes are found. The term is not entirely acceptable because there is no evidence that collagen is primarily involved; "collagen" was once synonymous with "connective tissue" rather than describing a specific fibrinous protein in that tissue. See also connective-tissue d.'s.
combined system d. subacute combined degeneration of the spinal cord
communicable d. any d. that is transmissible by infection or contagion directly or through the agency of a vector.
Concato's d. polyserositis
connective-tissue d.'s a group of generalized d.'s affecting connective tissue, especially those not inherited as mendelian characteristics; rheumatic fever and rheumatoid arthritis were first proposed as such d.'s, and other so-called collagen d.'s have been added.
Conradi's d. [MIM*215100 & MIM*302950] congenital shortening of the humerus and femur, with stippled epiphyses, high-arched palate, cataracts, erythroderma in the newborn, and scaling followed by follicular atrophoderma; there is also an autosomal dominant inheritance pattern [MIM*118650 and MIM*118651].chondrodystrophia congenita punctata;
contagious d. an infectious d. transmissible by direct or indirect contact; now used synonymously with communicable d.
Cori's d. type 3 glycogenosis
cornmeal d. See Besnoitia tarandi.
corridor d. a highly pathogenic disease of cape buffaloes (Syncerus caffer) and cattle in eastern and southern Africa caused by the protozoan Theileria parva lawrencei and transmitted primarily by the tick Rhipicephalus appendiculatus; lesions and symptoms are similar to those of East Coast fever.
Corrigan's d. aortic regurgitation
Cotunnius d. sciatica
Cowden's d. [MIM*158350] hypertrichosis and gingival fibromatosis from infancy, accompanied by postpubertal fibroadenomatous breast enlargement; papules of the face are characteristic of multiple trichilemmomas.multiple hamartoma syndrome;
crazy chick d. nutritional encephalomalacia of chicks
Creutzfeldt-Jakob d. (CJD) a type of subacute spongiform encephalopathy caused by a transmissible agent termed a prion. Affects adults, especially older adults, and is characterized by progressive dementia, myoclonic jerks, ataxia, and dysarthria; rapidly progressive and invariably fatal, usually within one year of onset. Often accompanied by a distinctive EEG pattern: burst suppression, consisting of intermittent sharp and slow wave complexes on a flat background. Pathologically, nerve cell degeneration and loss with associated astroglial proliferation are confined primarily to the cerebral and cerebellar cortices.Jakob-Creutzfeldt d., transmissible dementia;
Crigler-Najjar d. Crigler-Najjar syndrome
Crocq's d. acrocyanosis
Crohn's d. regional enteritis
Crouzon's d. craniofacial dysostosis
Cruveilhier-Baumgarten d. Cruveilhier-Baumgarten syndrome
Cruveilhier's d. amyotrophic lateral sclerosis
Csillag's d. chronic atrophic and lichenoid dermatitis.
Curschmann's d. frosted liver
Cushing's d. adrenal hyperplasia (Cushing's syndrome) caused by an ACTH-secreting basophil adenoma of the pituitary.Cushing's pituitary basophilism;
cystic d. of the breast fibrocystic condition of the breasts.
cystic d. of renal medulla [MIM*256100] presence of small cysts in the renal medulla associated with anemia, sodium depletion, and chronic renal failure. It is of two types: 1) fatal autosomal recessive or juvenile type (also called familial juvenile nephrophthisis), beginning at about age 10 with an average duration of 6 to 8 years; 2) autosomal dominant or adult type, beginning at about age 30 but with a more fulminant course.microcystic d. of renal medulla;
cysticercus d. cysticercosis
cystine d. cystinosis
cystine storage d. cystinosis
cytomegalic inclusion d. the presence of inclusion bodies within the cytoplasm and nuclei of enlarged cells of various organs of newborn infants dying with jaundice, hepatomegaly, splenomegaly, purpura, thrombocytopenia, and fever; the condition also occurs, at all ages, as a complication of other d.'s in which immune mechanisms are severely depressed, and has been found incidentally in salivary gland epithelium, apparently as a localized or mild infection (salivary gland virus d.).cytomegalovirus d., inclusion body d;
cytomegalovirus d. cytomegalic inclusion d
Daae's d. epidemic pleurodynia
Danielssen-Boeck d. anesthetic leprosy
Danielssen's d. anesthetic leprosy
Darier's d. keratosis follicularis
Darling's d. histoplasmosis
Davies' d. endomyocardial fibrosis
decompression d. decompression sickness
deer-fly d. tularemia
deficiency d. any d. resulting from undernutrition or an inadequacy of calories, proteins, essential amino acids, fatty acids, vitamins, or trace minerals.
degenerative joint d. osteoarthritis
Degos' d. malignant atrophic papulosis
Dejerine's d. Dejerine-Sottas d
Dejerine-Sottas d. a familial type of demyelinating sensorimotor polyneuropathy that begins in early childhood and is slowly progressive; clinically characterized by foot pain and paresthesias, followed by symmetrical weakness and wasting of the distal limbs; one of the causes of stork legs; patients are wheelchair bound at an early age; peripheral nerves are palpably enlarged and non-tender; pathologically, onion bulb formation is seen in the nerves: whorls of overlapping, intertwined Schwann cell processes that encircle bare axons; usually autosomal recessive inheritance.Dejerine's d., progressive hypertrophic polyneuropathy;
demyelinating d. generic term for a group of d.'s, of unknown cause, in which there is extensive loss of the myelin in the central nervous system, as in multiple sclerosis and Schilder's disease.
dense-deposit d. See membranoproliferative glomerulonephritis.
de Quervain's d. fibrosis of the sheath of a tendon of the thumb.radial styloid tendovaginitis;
Dercum's d. adiposis dolorosa
Derzsy's d. goose viral hepatitis
Deutschländer's d. 1. tumor of one of the metatarsal bones; 2. march fracture
Devic's d. neuromyelitis optica
diamond skin d. a form of swine erysipelas, caused by the bacterium Erysipelothrix rhusiopathiae, in which rhomboidal erythematous areas appear on the skin.
Di Guglielmo's d. the acute form of erythremic myelosis.
disappearing bone d. extensive decalcification of a single bone; of unknown cause, sometimes associated with angioma.Gorham's d;
diverticular d. symptomatic congenital or acquired diverticula of any portion of the gastrointestinal tract. Such diverticula occur in about 15% of the population but rarely cause symptoms.
dog d. phlebotomus fever
dominantly inherited Lévi's d. snub-nose dwarfism
Donohue's d. leprechaunism
drug-induced d. a toxic reaction to or morbid condition resulting from the administration of a drug.
Dubois' d. Dubois' abscesses, under abscess
Duchenne-Aran d. amyotrophic lateral sclerosis
Duchenne's d. 1. Duchenne dystrophy 2. progressive bulbar paralysis
Duhring's d. dermatitis herpetiformis
Dukes' d. an exanthem-producing infectious d. of childhood; unknown etiology.
Duncan's d. [MIM*308240] an X-linked recessive immunodeficiency and lymphoproliferative disease occurring in boys.
Duplay's d. subacromial bursitis
Dupuytren's d. of the foot plantar fibromatosis
Duroziez' d. congenital stenosis of the mitral valve.
Dutton's d. African tick-borne relapsing fever caused by Borrelia duttonii and spread by the soft tick, Ornithodoros moubata.Dutton's relapsing fever;
dynamic d. functional disorder
Eales' d. peripheral retinal periphlebitis causing recurrent retinal or intravitreous hemorrhages in young adults.
Ebstein's d. Ebstein's anomaly
echinococcus d. echinococcosisechinococciasis;
edema d. an acute, highly fatal d. of young pigs caused by toxins of the bacterium Escherichia coli and characterized by edema of various parts of the body but particularly the walls of the gastrointestinal tract.
Eisenmenger's d. Eisenmenger's complex
elephant man's d. Proteus syndrome
elevator d. respiratory distress arising in persons who work in grain elevators resulting from inhalation of dusts or insects.
emotional d. See mental illness.
endemic d. continued prevalence of a d. in a specific population or area. See also endemic, enzootic.
Engelmann's d. diaphysial dysplasia
English d. obsolete term for rickets.
English sweating d. a d. of unknown nature that appeared in England and spread over Europe in 1485, 1508 and 1528-30 and was characterized by heavy sweats, prostration, and a high fatality rate.sudor anglicus;
eosinophilic endomyocardial d. a restrictive cardiomyopathy associated with hyperproduction of eosinophiles and their cardiac infiltration, clinically characterized by diastolic and later systolic ventricular failure.
epidemic d. marked increase in prevalence of a d. in a specific population or area, usually with an environmental cause, such as an infectious or toxic agent.
epizootic hemorrhagic d. of deer a hemorrhagic disease of certain deer of the central and eastern United States, caused by an orbivirus, a member of the Reoviridae, and characterized by multiple hemorrhages, shock, and trauma; infection is thought to be arthropod-borne.hemorrhagic d. of deer;
Epstein's d. diphtheroid (1)
Erb d. progressive bulbar paralysis
Erb-Charcot d. 1. spastic diplegia 2. spastic paraplegia
Erdheim d. cystic medial necrosis
ergot alkaloid-associated heart d. heart d. caused by endomyocardial fibrosis which extends into valve structures, producing stenosis and/or regurgitation, associated with ergot alkaloid use.
Eulenburg's d. congenital paramyotonia
exanthematous d. See exanthema.
extramammary Paget d. an intraepidermal form of mucinous adenocarcinoma, most commonly in the anogenital region.Paget's d. (3);
extrapyramidal d. a general term for a number of disorders caused by abnormalities of the basal ganglia or certain brain stem or thalamic nuclei; characterized by motor deficits, loss of postural reflexes, bradykinesia, tremor, rigidity, and various involuntary movements.extrapyramidal motor system d;
extrapyramidal motor system d. extrapyramidal d
Fabry's d. [MIM*301500] an X-linked recessive disorder due to deficiency of a-galactosidase and characterized by abnormal accumulations of neutral glycolipids (e.g., globotriaosylceramide) in endothelial cells in blood vessel walls, with angiokeratomas on the thighs, buttocks, and genitalia, hypohidrosis, paresthesia in extremities, cornea verticillata, and spokelike posterior subcapsular cataracts; death results from renal, cardiac, or cerebrovascular complications.diffuse angiokeratoma, glycolipid lipidosis;
Fahr's d. progressive calcific deposition in the walls of blood vessels of the basal ganglia, in young to middle-aged persons; occasionally associated with mental retardation and extrapyramidal symptoms.
Farber's d. disseminated lipogranulomatosis
Favre-Durand-Nicholas d. venereal lymphogranuloma
Favre-Racouchet's d. comedones developing on sun-damaged skin due to obstruction of pilosebaceous follicles by solar elastosis.
Feer's d. acrodynia (2)
femoropopliteal occlusive d. obstruction of the femoral and popliteal arteries by atherosclerosis.
Fenwick's d. idiopathic gastric atrophy. See atrophic gastritis.
fibrocystic d. of the breast a benign d. common in women of the third, fourth, and fifth decades characterized by formation, in one or both breasts, of small cysts containing fluid which may appear as blue dome cysts; associated with stromal fibrosis and with variable degrees of intraductal epithelial hyperplasia and sclerosing adenosis.cystic hyperplasia of the breast;
fibrocystic d. of the pancreas cystic fibrosis
fifth d. erythema infectiosum [after scarlatina, morbilli, rubella, and fourth d.]
Filatov Dukes' d. an exanthem-producing infectious disease of childhood of unknown etiology.Filatov's d., fourth d., parascarlatina, scarlatinella;
Filatov's d. Filatov Dukes' d
fish eye d. an inherited disorder resulting in low HDL cholesterol and corneal opacities; also, low LCAT activity.
Flatau-Schilder d. Schilder's d
flax-dresser's d. chronic obstructive pulmonary d. caused by inhalation of particles of unprocessed flax; a form of byssinosis. See also byssinosis.
Flegel's d. hyperkeratosis lenticularis perstans
flint d. chalicosis
flip-over d. a d. of young, fast-growing broiler chickens which causes them to die suddenly with a short, terminal, wing-beating convulsion, whereby they often flip over and die on their backs.
focal metastatic d. presence of a single area of metastasis of a malignant tumor or infection distant from the primary lesion.
Folling's d. phenylketonuria
foot-and-mouth d. (FMD) a highly infectious disease of wide distribution and great economic importance, occurring in cattle, swine, sheep, goats and all wild and domestic cloven-footed animals caused by a picornavirus (genus Rhinovirus) and characterized by vesicular eruptions in the mouth, tongue, hoofs, and udder; humans are rarely affected.aftosa;
Forbes' d. type 3 glycogenosis
Fordyce's d. Fordyce's spots, under spot
Forestier's d. diffuse idiopathic skeletal hyperostosis
Fothergill's d. 1. trigeminal neuralgia 2. anginose scarlatina
Fournier's d. infective gangrene involving the scrotum.Fournier's gangrene, syphiloma of Fournier;
fourth d. Filatov Dukes' dscarlatinoid (2);
Fox-Fordyce d. a rare chronic pruritic eruption of dry papules and distended ruptured apocrine glands, with follicular hyperkeratosis of the nipples, axillae, and pubic and sternal regions.apocrine miliaria;
Franklin's d. gamma-heavy-chain d
Freiberg's d. epiphysial ischemic (aseptic) necrosis of second metatarsal head.
Friend d. mouse leukemia caused by the Friend leukemia virus, a member of the family Retroviridae.
functional d. functional disorder
functional cardiovascular d. a euphemism for cardiovascular symptoms deemed to be psychogenic. More generally, sometimes used for abnormal cardiac function.
fusospirochetal d. infection of the mouth and/or pharynx associated with fusiform bacilli and spirochetes, commonly part of the normal flora of the mouth. See also necrotizing ulcerative gingivitis.
Gairdner's d. attacks of cardiac distress accompanied by apprehension.angina pectoris sine dolore, angor pectoris (1);
Gamna's d. a form of chronic splenomegaly characterized by conspicuous thickening of the capsule and the presence of multiple, small, rustlike, brown foci (Gamna-Gandy bodies), which contain iron; this condition may be observed in fibrocongestive splenomegaly, sickle cell d., and some examples of hemochromatosis.
Gandy-Nanta d. siderotic splenomegaly, probably the same as Gamna's d.
garapata d. tick fever occurring in Spain.
Garré's d. sclerosing osteitis
gasping d. infectious avian bronchitis
Gaucher's d. a lysosomal storage d. resulting from glycocerebroside accumulation due to a genetic deficiency of glucocerebrosidase; may occur in adults but occurs most severely in infants; marked by hepatosplenomegaly, regression of neurological maturation, and characteristic histiocytes (Gaucher cells) in the viscera; autosomal recessive inheritance. There are three main types: the noncerebral juvenile [MIM*230800], the cerebral juvenile [MIM* 230900], and the adult cerebral [MIM*231000].cerebroside lipidosis, familial splenic anemia, Gaucher disorder;
Gerhardt-Mitchell d. erythromelalgia
Gerhardt's d. erythromelalgia
Gerlier's d. vestibular neuronitis
Gierke's d. type 1 glycogenosis
Gilbert's d. familial nonhemolytic jaundice
Gilchrist's d. blastomycosis
Gilles de la Tourette's d. Tourette syndrome
Glanzmann's d. Glanzmann's thrombasthenia
Glasser's d. a fibrinous polyserositis, polyarthritis, and meningitis of pigs caused by the bacterium Haemophilus parasuis.
glycogen-storage d. glycogenosis
Goldflam d. myasthenia gravis
Gorham's d. disappearing bone d
Gougerot and Blum d. pigmented purpuric lichenoid dermatosis
Gougerot-Sjögren d. Sjögren's syndrome [Sjögren, Henrik S.C.]
Gowers d. 1. saltatory spasm 2. a distal type of progressive muscular dystrophy.
graft versus host d. an incompatibility reaction (which may be fatal) in a subject (host) of low immunological competence (deficient lymphoid tissue) who has been the recipient of immunologically competent lymphoid tissue from a donor who lacks at least one antigen possessed by the recipient host; the reaction, or disease, is the result of action of the transplanted cells against those host tissues that possess the antigen not possessed by the donor. Seen most commonly following bone marrow transplantation, acute d. is seen after 5-40 days and chronic d. weeks to months after transplantation, affecting, principally, the gastrointestinal tract, liver, and skin.GVH d;
granulomatous d. chronic granulomatous d
Graves' d. 1. toxic goiter characterized by diffuse hyperplasia of the thyroid gland, a form of hyperthyroidism; exophthalmos is a common, but not invariable, concomitant; 2. thyroid dysfunction and all or any of its clinical associations; 3. an organ-specific autoimmune disease of the thyroid gland. See thyrotoxicosis, Hashimoto's thyroiditis, goiter, myxedema.Basedow's d., ophthalmic hyperthyroidism, Parry's d;
greasy pig d. a generalized exudative epidermitis of young pigs, characterized by high mortality and caused by staphylococcal bacteria.
Greenhow's d. parasitic melanoderma
Griesinger's d. bilious typhoid of Griesinger, a severe form of louse-borne relapsing fever caused by Borrelia recurrentis and causing high fever, epistaxis, dyspnea, intense jaundice, purpura, and splenomegaly.
Grover's d. transient acantholytic dermatosis
Gumboro d. infectious bursal d
GVH d. graft versus host d
Haff d. hemoglobinuria, muscular weakness, and pains in the limbs, occurring in persons living in the vicinity of the Haff inlet, caused by arsenic poisoning from waste in a celluloid factory. [Haff, an arm of the Baltic Sea in East Prussia]
Haglund's d. an abnormal prominence of the posterior superior lateral aspect of the os calcis, caused by a gait disorder.Haglund's deformity;
Hailey-Hailey d. benign familial chronic pemphigus
hairy shaker d. border d
Hallervorden-Spatz d. Hallervorden-Spatz syndrome
Hallopeau's d. 1. pustulosis palmaris et plantaris 2. pemphigus vegetans (2)
Hamman's d. Hamman's syndrome
Hammond's d. athetosis
hand-foot-and-mouth d. an exanthematous eruption of small, pearl-gray vesicles of the fingers, toes, palms, and soles, accompanied by often painful vesicles and ulceration of the buccal mucous membrane and the tongue and by slight fever; the d. lasts 4 to 7 days, and is usually caused by Coxsackie virus type A-16, but other types have been identified.
Hand-Schüller-Christian d. the chronic disseminated form of Langerhans cell histiocytosis. The classic triad of signs consists of diabetes insipidus, exopthalmus, and bony lesions composed of histiocytes.Christian's d. (1) , Christian's syndrome, normal cholesteremic xanthomatosis, Schüller's d., Schüller's syndrome;
Hansen's d. Chronic granulomatous infection caused by Mycobacterium leprae (Hansen's bacillus) and affecting various parts of the body including the skin.leprosy (2);
Harada's d. Harada's syndrome
hard pad d. a form of canine distemper characterized by hyperkeratosis of the foot pads and nose. See canine distemper.
hardware d. traumatic gastritis
Hartnup d. [MIM*234500] a congenital metabolic disorder consisting of aminoaciduria due to a defect in renal tubular absorption of neutral a-amino acids and urinary excretion of tryptophan derivatives, because defective intestinal absorption leads to bacterial degradation of unabsorbed tryptophan in the gut; characterized by a pellagra-like, light-sensitive skin rash with temporary cerebellar ataxia; autosomal recessive inheritance.Hartnup disorder, Hartnup syndrome;
Hashimoto's d. Hashimoto's thyroiditis
heavy chain d. a term used for a group of d.'s, the paraproteinemias, characterized by production of homogenous immunoglobulins or fragments, and associated with malignant disorders of the plasmacytic and lymphoid cell series. Three types have been recognized: gamma-heavy-chain d., a-heavy-chain d., and mu-heavy-chain d.; each is diagnosed by the finding of the appropriate heavy-chain fragment in the serum, urine, or both.
a-heavy-chain d. the most common form of heavy-chain d., characterized by a finding in the serum of a protein reactive with antisera to a-chains but not light chains; clinical features include diarrhea, steatorrhea, and severe malabsorption.
gamma-heavy-chain d. heavy-chain d. characterized by a finding in the serum and urine of a broad protein peak that is reactive with antisera to gamma-chains and unreactive with antisera to light chains; common features include anemia, lymphocytosis, eosinophilia, thrombocytopenia, hyperuricemia, lymphadenopathy, and hepatosplenomegaly.Franklin's d;
mu-heavy-chain d. the rarest form of heavy-chain d., primarily seen in patients with long-standing chronic lymphatic leukemia; diagnosis is made on immunoelectrophoresis by finding a component reactive with antisera to mu-chains but not to light chains.
Hebra's d. 1. erythema multiforme 2. familial nonhemolytic jaundice
Heck's d. focal epithelial hyperplasia
Heerfordt's d. uveoparotid fever
hemoglobin C d. the homozygous state of hemoglobin C.
hemoglobin H d. See hemoglobin H.
hemolytic d. of newborn erythroblastosis fetalis
hemorrhagic d. of deer epizootic hemorrhagic d. of deer
hemorrhagic d. of the newborn a syndrome characterized by spontaneous internal or external bleeding accompanied by hypoprothrombinemia, slightly decreased platelets, and markedly elevated bleeding and clotting times, usually occurring between the third and sixth days of life and effectively treated with vitamin K.
hepatolenticular d. Wilson's d. (1)
herring-worm d. anisakiasis
Hers' d. type 6 glycogenosis
hidebound d. scleroderma (usually applied to extensive involvement).
Hirschsprung's d. congenital megacolon
Hjärre's d. a granulomatous d. of the intestines and liver of chickens, due to coliform organisms.coli granuloma;
Hodgkin's d. a d. marked by chronic enlargement of the lymph nodes, often local at the onset and later generalized, together with enlargement of the spleen and often of the liver, no pronounced leukocytosis, and commonly anemia and continuous or remittent (Pel-Ebstein) fever; considered to be a malignant neoplasm of lymphoid cells of uncertain origin (Reed-Sternberg cells), associated with inflammatory infiltration of lymphocytes and eosinophilic leukocytes and fibrosis; can be classified into lymphocytic predominant, nodular sclerosing, mixed cellularity, and lymphocytic depletion type; a similar disease occurs in domestic cats.Hodgkin's lymphoma, lymphadenoma (2);
Hodgson's d. dilation of the arch of the aorta associated with insufficiency of the aortic valve.
holoendemic d. (hol´o-en-dem´ik) a d. for which a high prevalent level of infection begins early in life and affects most or all of the child population, leading to a state of equilibrium, such that the adult population shows evidence of the disease much less frequently than do the children.
hoof-and-mouth d. obsolete term for foot-and-mouth d.
hookworm d. See ancylostomiasis, necatoriasis.
Huntington's d. [MIM*143100] Huntington's chorea
Hurler's d. Hurler's syndrome
Hutchinson-Gilford d. progeria
hyaline membrane d. of the newborn a d. seen especially in premature neonates with respiratory distress; characterized postmortem by atelectasis and alveolar ducts lined by an eosinophilic membrane; also associated with reduced amounts of lung surfactant.hyaline membrane syndrome, respiratory distress syndrome of the newborn;
hydatid d. infection of humans, sheep, and most other herbivorous and omnivorous mammals with larvae of the tapeworm Echinococcus.
Hyde's d. prurigo nodularis
hyperendemic d. (hI´per-en-dem´ik) a d. that is constantly present at a high incidence and/or prevalence rate and affects all age groups equally.
Iceland d. epidemic neuromyasthenia
I-cell d. mucolipidosis II
idiopathic d. a d. of unknown cause or mechanism.
immune complex d. an immunologic category of d.'s evoked by the deposition of antigen-antibody or antigen-antibody-complement complexes on cell surfaces, with subsequent involvement of breakdown products of complement, platelets, and polymorphonuclear leukocytes, and development of vasculitis; nephritis is common. Arthus phenomenon and serum sickness are classic examples, but many other disorders, including most of the connective tissue d.'s, may belong in this immunologic category; immune complex d.'s can also occur during a variety of d.'s of known etiology, such as subacute bacterial endocarditis. See also autoimmune d.immune complex disorder, type III hypersensitivity reaction;
immunoproliferative small intestinal d. diffuse lymphoplasmacytic infiltration of the proximal small bowel mucosa and mesenteric lymph nodes resulting in diarrhea, weight loss, abdominal pain, and clubbing of fingers and toes; seen in poor people in developing countries.Mediterranean lymphoma;
inborn lysosomal d. inherited disorder of one or more degradative enzymes normally located in lysosomes leading to accumulation (storage) of abnormal quantities of a substance, such as a glycosaminoglycan as in Hurler's syndrome or a lipopolysaccharide as in Gaucher's d.
inclusion body d. cytomegalic inclusion d
inclusion cell d. mucolipidosis II
industrial d. a morbid condition resulting from exposure to an agent discharged by a commercial enterprise into the environment. Cf. occupational d.
infantile celiac d. gluten-sensitive enteropathy appearing in infancy, often before the age of 9 months and characterized by acute onset, diarrhea, abdominal pain, and "failure to thrive."
infectious d. , infective d. a d. resulting from the presence and activity of a microbial agent.
infectious bursal d. a highly contagious acute d. of chickens caused by the infectious bursal disease virus and characterized by whitish diarrhea, dehydration, prostration, and destruction of the bursa of Fabricius, compromising the bird's immune system.Gumboro d;
intercurrent d. a new d. occurring during the course of another d., not related to the primary disease process.
interstitial d. a d. occurring chiefly in the connective-tissue framework of an organ, the parenchyma suffering secondarily.
iron-storage d. the storage of excess iron in the parenchyma of many organs, as in idiopathic hemochromatosis or transfusion hemosiderosis.
island d. tsutsugamushi d
Itai-Itai d. a form of cadmium poisoning described in Japanese people, characterized by renal tubular dysfunction, osteomalacia, pseudofractures, and anemia, caused by ingestion of contaminated shellfish or other sources containing cadmium.
Jaffe-Lichtenstein d. obsolete term for fibrous dysplasia of bone.
Jakob-Creutzfeldt d. Creutzfeldt-Jakob d
Jansky-Bielschowsky d. cerebral sphingolipidosis, early juvenile type.
Jembrana d. a febrile d. of cattle thought to be caused by a rickettsia of the genus Ehrlichia. [Jembrana, county in Bali, Indonesia, where disease was first recognized]
Jensen's d. retinochoroiditis juxtapapillaris
Johne's d. a d. occurring in cattle and sheep, usually manifested by thickening of the wall of the intestine, particularly of the ileum; caused by infection with Mycobacterium paratuberculosis.chronic dysentery of cattle, paratuberculosis;
jumping d. , jumper d. one of the pathological startle syndromes found in isolated parts of the world, characterized by greatly exaggerated responses, such as jumping, flinging the arms and yelling, to minimal stimuli.jumping Frenchmen of Maine d., jumper d. of Maine;
jumping Frenchmen of Maine d. , jumper d. of Maine jumping d
Jüngling's d. osteitis tuberculosa multiplex cystica
Kashin-Bek d. a form of generalized osteoarthrosis limited to areas of Asia, including the Urov river; believed to result from ingestion of wheat infected with the fungus Fusarium sporotrichiella.
Katayama d. acute early egg-laying phase of schistosomiasis, a toxemic syndrome in heavy primary infections, rarely seen in chronic cases. It is considered a form of immune complex d. or serum sickness-like condition. Described for schistosomiasis japonica, but observed with other forms as well.Katayama fever; [town in Japan where the d. is common]
Kawasaki's d. mucocutaneous lymph node syndrome
Kennedy's d. an X-linked recessive disorder characterized by progressive spinal and bulbar muscular atrophy; associated features include distal degeneration of sensory axons, and signs of endocrine dysfunction, including diabetes mellitus, gynecomastia, and testicular atrophy.
Kienböck's d. osteolysis of the lunate bone following trauma to the wrist.lunatomalacia;
Kimmelstiel-Wilson d. Kimmelstiel-Wilson syndrome
Kimura's d. angiolymphoid hyperplasia with eosinophilia
kinky-hair d. , kinky hair d. [MIM*309400] congenital defect of copper metabolism manifested in short, sparse, poorly pigmented kinky hair; associated with failure to thrive, physical and mental retardation, and progressive severe deterioration of the brain; apparently a defect of copper transport; X-linked recessive inheritance.kinky-hair disorder, Menkes' syndrome, trichopoliodystrophy;
Köhler's d. epiphysial aseptic necrosis of the tarsal navicular bone or of the patella.
Krabbe's d. globoid cell leukodystrophy
Kufs d. cerebral sphingolipidosis, adult type.
Kugelberg-Welander d. juvenile spinal muscular atrophy
Kuhnt-Junius d. Kuhnt-Junius degeneration
Kussmaul's d. polyarteritis nodosa
Kyasanur Forest d. a d. occurring among forest workers in the Kyasanur Forest and in Mysore, India, caused by a group B arbovirus (Flavivirus) transmitted chiefly by Haemaphysalis spinigera, although other ticks have been implicated as well; symptoms include fever, headache, back and limb pains, diarrhea, and intestinal bleeding; central nervous system symptoms do not occur.
Kyrle's d. hyperkeratosis follicularis et parafollicularis
Lafora body d. [MIM*254780] a form of progressive myoclonus epilepsy beginning from age 6 to 19; characterized by generalized tonic-clonic seizures, resting and action myoclonus, ataxia, dementia, and classic EEG findings, including polyspike and wave discharges; basophilic cytoplasmic inclusion bodies present in portions of the brain, the liver, and skin, as well as the duct cells of the sweat glands. Death usually occurs within 10 years of onset; autosomal recessive inheritance.Lafora's d;
Lafora's d. Lafora body d
Lane's d. erythema palmare hereditarium
Larrey-Weil d. Weil's d
Lasègue's d. obsolete eponym for delusions of persecution.
laughing d. 1. a disabling state of hypnosis or narcosis induced by witch doctors and characterized by involuntary laughing; 2. the compulsive mirthless laughter of schizophrenics.
L-chain d. Bence Jones myeloma
Legg-Calvé-Perthes d. , Legg's d. , Legg-Perthes d. epiphysial aseptic necrosis of the upper end of the femur.Calvé-Perthes d., coxa plana, osteochondritis deformans juvenilis, Perthes d., pseudocoxalgia, quiet hip d;
Legionnaire's d. an acute infectious d., caused by Legionella pneumophila, with prodromal influenza-like symptoms and a rapidly rising high fever, followed by severe pneumonia and production of usually nonpurulent sputum, mental confusion, hepatic fatty changes, and renal tubular degeneration. It has a high case-fatality rate. Acquired from water systems rather than person to person.legionellosis; [American Legion convention, 1976, at which many delegates were so affected]
Leigh's d. subacute encephalomyelopathy affecting infants, causing dementia, spasticity, and optic atrophy; autosomal recessive inheritance.necrotizing encephalomyelopathy, necrotizing encephalopathy;
Leiner's d. erythroderma desquamativum
Lenègre's d. Lenègre's syndrome
Leri-Weill d. dyschondrosteosis
Letterer-Siwe d. the acute disseminated form of Langerhans cell histiocytosis.nonlipid histiocytosis;
Lev's d. Lev's syndrome
Lindau's d. von Hippel-Lindau syndrome
linear IgA bullous d. in children chronic bullous dermatosis of childhood
Little's d. spastic diplegia
Lobo's d. lobomycosis
locoweed d. loco
Löffler's d. Löffler's endocarditis
Lorain's d. idiopathic infantilism
Lou Gehrig's d. amyotrophic lateral sclerosis
Luft's d. [MIM*238800] a metabolic d. due to relative uncoupling of phosphorylation in skeletal muscle causing myopathy and general hypermetabolism; a mitochondial myopathy.
lumpy skin d. an infectious d. of cattle in Africa, manifested by an acute febrile illness followed by the appearance of lumps and plaques under the skin and on some of the mucous membranes; caused by the lumpy skin disease virus.
lung fluke d. infection with the lung fluke, Clonorchis sinensis.
Lutz-Splendore-Almeida d. paracoccidioidomycosis
Lyell's d. staphylococcal scalded skin syndrome
Lyme d. an inflammatory disorder typically occurring during the summer months and caused by Borrelia burgdorferi, a non-pyogenic, penicillin-sensitive spirochete transmitted by Ixodes dammini in the eastern U.S. and I. pacificus in the western U.S.; the characteristic skin lesion, erythema chronicum migrans, usually is preceded or accompanied by fever, malaise, fatigue, headache, and stiff neck; neurologic or cardiac manifestations, or arthritis (Lyme arthritis) may occur weeks to months later. Dogs, horses, and cattle are also affected.Lyme borreliosis; [Lyme, CT, where first observed] Because of media coverage, Lyme disease has a higher profile than its occurrence warrants. In 1993, there were 9,350 confirmed cases in the U.S. Prototype vaccines against Borrelia burgdorferi have proved effective in mice. However, the spirochete is thought capable of rapid mutation, so work on future human vaccines must address the possibility of multiple strains.
lysosomal d. a d. due to inadequate functioning of a lysosomal enzyme; most such d.'s are associated with a storage d.
Machado-Joseph [MIM*109150] a rare form of hereditary ataxia, characterized by onset in early adult life of progressive, spinocerebellar and extrapyramidal disease with external ophthalmoplegia, rigidity dystonia symptoms, and, often, peripheral amyotrophy; found predominantly in people of Azorean ancestry; autosomal dominant inheritance.Azorean d., Portuguese-Azorean d; [Surnames of two families studied in major descriptions of the disease.]
mad cow d. bovine spongiform encephalopathy
Madelung's d. multiple symmetric lipomatosis
Majocchi's d. purpura annularis telangiectodes
Manson's d. schistosomiasis mansoni
maple bark d. hypersensitivity pneumonitis caused by spores of Cryptostroma corticale growing under the bark of stacked maple logs.
maple syrup urine d. [MIM*248600] a disorder caused by deficient oxidative decarboxylation of a-keto acid metabolites of leucine, isoleucine, and valine which are present in blood and urine in high concentrations, the urine having an odor similar to that of maple syrup; neonatal death is common; survivors usually exhibit gross brain damage; autosomal recessive inheritance.branched chain ketoaciduria, branched chain ketonuria, ketoacidemia;
marble bone d. osteopetrosis
Marburg d. infection with an unusual rhabdovirus composed of RNA and lipid, tentatively assigned to the family of Filoviridae. Virus is "pantropic" and affects most organ systems.The disease is characterized by a prominent rash and hemorrhages in many organs and is often fatal. First seen among laboratory workers in Marburg, Germany, exposed to African green monkeys. Some person-to-person spread has been observed. Attempts to isolate virus should be done only in high-security laboratories.Marburg virus d;
Marburg virus d. Marburg d
Marchiafava-Bignami d. a disorder recognized primarily by its pathological features, consisting of demyelination of the corpus callosum and cortical laminar necrosis involving the frontal and temporal lobes. Occurs predominantly in chronic alcoholics, particularly wine drinkers.
Marek's d. See avian lymphomatosis.
Marfan's d. Marfan's syndrome
margarine d. erythema multiforme caused by an emulsifying agent used in the manufacture of margarine.
Marie's d. a hypertrophic osteopathy of dogs in which osseous changes of the limbs are associated with intrathoracic lesions such as pulmonary neoplasms; also occurs in horses, cattle, and sheep.
Marie-Strümpell d. ankylosing spondylitis
Marion's d. a congenital obstruction of the posterior urethra.
Martin's d. a periosteoarthritis of the foot from excessive walking.
McArdle's d. type 5 glycogenosis
McArdle-Schmid-Pearson d. type 5 glycogenosis
mechanobullous d. (mek´an-o-bul-ous) epidermolysis bullosa [G. mechane, machine, + bullous]
Meige's d. [MIM*153200] autosomal dominant lymphedema with onset at about the age of puberty.
Ménétrier's d. gastric mucosal hyperplasia, either mucoid or glandular; the latter type may be associated with the Zollinger-Ellison syndrome.giant hypertrophy of gastric mucosa, hypertrophic gastritis, Ménétrier's syndrome;
Ménière's d. an affection characterized clinically by vertigo, nausea, vomiting, tinnitus, and progressive deafness due to swelling of the endolymphatic duct.auditory vertigo, endolymphatic hydrops, labyrinthine vertigo, Ménière's syndrome;
mental d. See mental illness.
Merzbacher-Pelizaeus d. Pelizaeus-Merzbacher d
metabolic d. generic term for disease caused by an abnormal metabolic process. It can be a congenital due to inherited enzyme abnormality or acquired due to disease of an endocrine organ or failure of function of a metabolic important organ such as the liver.
Meyenburg's d. relapsing polychondritis
Meyer-Betz d. myoglobinuria
mianeh d. Persian relapsing fever
Mibelli's d. porokeratosis
microcystic d. of renal medulla cystic d. of renal medulla
micrometastatic d. the condition of a patient who has had all clinically evident cancer removed, but who may be expected to have a recurrence from metastases that are too small to be apparent.
Mikulicz' d. benign swelling of the lacrimal, and usually also of the salivary glands in consequence of an infiltration of and replacement of the normal gland structure by lymphoid tissue. See also Mikulicz' syndrome, Sjögren's syndrome.
Milian's d. ninth-day erythema
Milroy's d. [MIM*153100] the congenital type of autosomal dominant lymphedema.
Milton's d. angioedema
Minamata d. a neurologic disorder caused by methyl mercury intoxication; first described in the inhabitants of Minamata Bay, Japan, resulting from their eating fish contaminated with mercury industrial waste. Characterized by peripheral sensory loss, tremors, dysarthria, ataxia, and both hearing and visual loss.
miner's d. 1. ancylostomiasis, miner's nystagmus
minimal-change d. lipoid nephrosis
Mitchell's d. erythromelalgia
mixed connective-tissue d. d. with overlapping features of various systemic connective-tissue d.'s and with serum antibodies to nuclear ribonucleoprotein.
molecular d. a d. in which the manifestations are due to alterations in molecular structure and function.
Mondor's d. thrombophlebitis of the thoracoepigastric vein of the breast and chest wall.
Monge's d. chronic mountain sickness
Morgagni's d. Adams-Stokes syndrome
Morquio's d. Morquio's syndrome
Morquio-Ullrich d. Morquio's syndrome
Morvan's d. syringomyelia
Moschcowitz' d. thrombotic thrombocytopenic purpura
motor neuron d. (MND) a general term including progressive spinal muscular atrophy (infantile, juvenile, and adult), amyotrophic lateral sclerosis, progressive bulbar paralysis, and primary lateral sclerosis; frequently a familial d.motor system d;
motor system d. motor neuron d
mountain d. a term that can mean acute altitude sickness; also used for chronic disease characterized by low oxygen saturation of hemoglobin, due to low partial pressure of oxygen in inspired air plus alveolar hypoventilation that develops in some individuals, especially older people. Polycythemia leads to florid skin color but cyanosis appears on mild exertion, along with dyspnea, fatigue, headache, and mental torpor. A person so afflicted returns to normal shortly after return to lower altitude.
moyamoya d. a cerebrovascular disorder occurring predominantly in the Japanese, in which the vessels of the base of the brain become occluded and revascularized with a fine network of vessels; it occurs commonly in young children and is manifested by convulsions, hemiplegia, mental retardation, and subarachnoid hemorrhage; the diagnosis is made by the angiographic picture. [Jap. addlebrained]
Mucha-Habermann d. pityriasis lichenoides et varioliformis acuta
mucosal d. bovine virus diarrhea
multicore d. nonprogressive congenital myopathy characterized by weakness of proximal muscles, multifocal degeneration of the muscle fibers, and eccentric areas of decreased or absent oxidative enzyme activity in muscles.
Nairobi sheep d. a d. of sheep in East Africa caused by Nairobi sheep d. virus, a member of the family Bunyaviridae, transmitted by Rhipicephalus appendiculatus, and characterized by hemorrhagic gastroenteritis with high fever.
navicular d. a common cause of lameness in horses, especially light racing animals; it is essentially a chronic osteitis of the navicular bone associated with bursitis and inflammation of the plantar aponeurosis; occurs most frequently in the forefeet and is believed to be due to damage from frequent and severe strain.navicularthritis;
Neftel's d. paresthesia of the head and trunk, and extreme discomfort in any but the recumbent position.
Neumann's d. pemphigus vegetans (1)
neutral lipid storage d. Dorfman-Chanarin syndrome
Newcastle d. an acute febrile, and contagious d. of fowls resembling fowl plague, caused by a Paramyxovirus (Newcastle d. virus) and characterized by high infectivity and respiratory and nervous symptoms; it is readily transmissible to man, in whom it causes a severe but transient conjunctivitis.Ranikhet d; [Newcastle upon Tyne, England, where first reported]
new duck d. infectious serositis
Nicolas-Favre d. venereal lymphogranuloma
Niemann d. Niemann-Pick d
Niemann-Pick d. [MIM*257200] lipid histiocytosis with accumulation of sphingomyelin in histiocytes in the liver, spleen, lymph nodes, and bone marrow; cerebral involvement may occur at a late stage, with red macular spots less common than in Tay-Sachs d.; occurs most commonly in Jewish infants and leads to early death; a more benign form may occur rarely in adults; autosomal recessive inheritance. Type I Neimann-Pick d. is due to a deficiency of sphingomyelinase; the cause of Type II Niemann-Pick d. (or, secondary Niemann-Pick d.) is unknown.Niemann d., sphingomyelin lipidosis;
nil d. lipoid nephrosis
nodular d. oesophagostomiasis in herbivores and primates, characterized by nodules in the wall of the large intestine, cecum, and occasionally, the ileum; the nodules are filled with caseous material and result from host response to encystment of the larvae of Oesophagostomum species.
Norrie's d. [MIM*310600] congenital bilateral masses of tissue arising from the retina or vitreous and resembling glioma (pseudoglioma), usually with atrophy of iris and development of cataract; associated mental retardation and deafness; X-linked recessive inheritance.
notifiable d. a d. that, by statutory requirements, must be reported to the public health or veterinary authorities when the diagnosis is made because of its importance to human or animal health.reportable d;
oasthouse urine d. [MIM*250900] an inherited metabolic defect in the absorption of methionine which is converted by intestinal bacteria to a-hydroxybutyric acid; characterized by diarrhea, tachypnea, and marked urinary excretion of a-hydroxybutyric acid (causing an odor like that of an oasthouse). [oast, kiln for drying hops, malt, or tobacco]
occupational d. a morbid condition resulting from exposure to an agent during the usual performance of one's occupation. Cf. industrial d.
Ofuji's d. eosinophilic pustular folliculitis
Oguchi's d. [MIM*258100] a rare, congenital, nonprogressive night blindness with yellow or gray coloration of fundus; after 2 or 3 hours in total darkness, normal color of fundus returns; autosomal recessive inheritance.
Ollier's d. enchondromatosis
Ondiri d. bovine petechial fever
Oppenheim's d. amyotonia congenita (1)
organic d. a d. in which there are anatomical or pathophysiological changes in some bodily tissue or organ, in contrast to a functional disorder; particularly one of psychogenic origin.
Ormond's d. retroperitoneal fibrosis
orphan d. a d. for which no treatment has been developed because of its rarity (affecting no more than 200,000 persons in the U.S.). See also orphan products, under product.
Osgood-Schlatter d. epiphysial aseptic necrosis of the tibial tubercle.apophysitis tibialis adolescentium, Schlatter's d., Schlatter-Osgood d;
Osler's d. 1. polycythemia vera
Osler-Vaquez d. polycythemia vera
Otto's d. a d. characterized by an inward bulging of the acetabulum into the pelvic cavity, resulting from arthritis of the hip joints, usually due to rheumatoid arthritis.arthrokatadysis, Otto pelvis, protrusio acetabuli;
Owren's d. [MIM*227400] a congenital deficiency of factor V, resulting in prolongation of prothrombin time and coagulation time.
Paas' d. a familial skeletal deformation marked by coxa valga, double patella, shortening of the middle and terminal phalanges of fingers and toes, deformities of the elbows, scoliosis, and spondylitis deformans of the lumbar vertebrae; all of these manifestations may be unilateral or bilateral.
Pacheco's d. a highly contagious, acute d. of psittacine birds caused by a herpesvirus and characterized by bright yellow urates with scant feces, icterus, and terminal anorexia.
Paget's d. 1. a generalized skeletal disease, frequently familial, of older persons in which bone resorption and formation are both increased, leading to thickening and softening of bones (e.g., the skull), and bending of weight-bearing bones;osteitis deformans; 2. a d. of elderly women, characterized by an infiltrated, somewhat eczematous lesion surrounding and involving the nipple and areola, and associated with subjacent intraductal cancer of the breast and infiltration of the lower epidermis by malignant cells; 3. extramammary Paget d
Panner's d. epiphysial aseptic necrosis of the capitellum of the humerus.
paper mill worker's d. extrinsic allergic alveolitis caused by moldy wood pulp containing spores of Alternaria fungi.
parasitic d. a d. due to the presence and vital activity of a parasite, or as a reaction to a parasite.
Parkinson's d. parkinsonism (1)
parrot d. psittacosis
Parrot's d. 1. pseudoparalysis in infants, due to syphilitic osteochondritis; 2. marasmus
Parry's d. Graves' d
Pauzat's d. osteoplastic periostitis or fatigue fractures of the metatarsal bones, caused by excessive marching.
Pavy's d. cyclic or recurrent physiologic albuminuria.
Paxton's d. trichomycosis axillaris
pearl-worker's d. inflammatory hypertrophy of the bones affecting grinders of mother-of-pearl.
Pel-Ebstein d. Pel-Ebstein fever
Pelizaeus-Merzbacher d. [MIM*260600] a sudanophilic leukodystrophy with a tigroid appearance of the myelin resulting from patchy demyelination. Type 1-classic, nystagmus and tremor appearing in the first few months of life, followed by slow motor development sometimes with choreoathetosis, spasticity, optic atrophy and seizures, with death in early adulthood, X-linked recessive inheritance; type 2-contralateral form with death in months to years after birth, X-linked recessive inheritance; type 3-transitional, with death in the first decade; type 4-adult form associated with involuntary movements, ataxia and hyperreflexia, but without nystagmus; type 5-variant forms. Cockayne is sometimes included as a sixth form.Merzbacher-Pelizaeus d;
Pellegrini's d. a calcific density in the medial collateral ligament and/or bony growth at the internal condyle of the femur.Pellegrini-Stieda d;
Pellegrini-Stieda d. Pellegrini's d
pelvic inflammatory d. (PID) acute or chronic inflammation in the pelvic cavity, particularly, suppurative lesions of the upper female genital tract; e.g., salpingitis and its complications.PID is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea, that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion. It may be either symptomatic (acute phase, 5-10 days and subsequently symptom free) or asymptomatic. The rate of PID varies with age group, with the highest rate reported in women 20-29 years old. Because of scarring damage, PID accounts for a share of tubal infertility (estimated at 1.7% in the U.S., based on 1988 figures). It also may raise the risk of ectopic pregnancy (about a 1 in 16 chance for women who have had PID, versus 1 in 147 for all women).
periodic d. any condition or d. in which episodes tend to recur at regular intervals; many such cases are manifestations of familial Mediterranean fever; the cause of the periodicity is usually unknown.
perna d. halogen or chloric acne occurring in workers in perchlornaphthalin. [perchlornaphthalin]
Perthes d. Legg-Calvé-Perthes d
Pette-Döring d. nodular panencephalitis
Peyronie's d. a d. of unknown cause in which there are plaques or strands of dense fibrous tissue surrounding the corpus cavernosum of the penis, causing deformity and painful erection; sometimes associated with Dupuytren's contracture.penile fibromatosis, van Buren's d;
Pick's d. progressive circumscribed cerebral atrophy; a rare type of cerebrodegenerative disorder manifested primarily as dementia, in which there is striking atrophy of portions of the frontal and temporal lobes.Pick's syndrome; [F. Pick]
pink d. acrodynia (2)
plaster of Paris d. atrophy of bone in a limb which has been encased for some time in a plaster of Paris splint.
Plummer's d. eponym sometimes applied to hyperthyroidism resulting from a nodular toxic goiter, usually not accompanied by exophthalmos.
polycystic d. of kidneys polycystic kidney
polycystic liver d. polycystic liver
Pompe's d. type 2 glycogenosis
Portuguese-Azorean d. Machado-Joseph
Posadas d. coccidioidomycosis
Potter's d. Potter's facies
Pott's d. tuberculous spondylitis
poultry handler's d. extrinsic allergic alveolitis similar to bird-breeder's lung, caused by inhalation of particulate emanations from domesticated fowl such as chickens and turkeys.
pregnancy d. of sheep a highly fatal metabolic d. of well-nourished ewes in the late stages of pregnancy, especially in ewes carrying twin lambs; it is caused by carbohydrate depletion of the blood and tissues, and is characterized by hypoglycemia, ketonuria, fatty infiltration of the liver, rapid emaciation, coma, and a high death rate.lambing paralysis, lambing sickness;
primary d. a d. that arises spontaneously and is not associated with or caused by a previous disease, injury, or event, but which may lead to a secondary d.
Pringle's d. adenoma sebaceum
pseudo-Hurler d. infantile, generalized GM1 gangliosidosis
pullorum d. an infectious d. of chicks and other young birds caused by the bacterium Salmonella pullorum, which is carried in the ovaries of adult hens and appears in the eggs; in incubator-hatched birds, the d. usually involves the lungs and air sacs, but often spreads in flocks of young birds as an alimentary tract infection manifested by severe diarrhea followed by septicemia and death.diarrhea alba, white diarrhea;
pulpy kidney d. an enterotoxemia of sheep caused by the bacterium Clostridium perfringens type D and characterized by sudden death preceded in some cases by excitement, incoordination, and convulsions; also occurs in goats and rarely in cattle.
pulseless d. Takayasu's arteritis
Purtscher's d. Purtscher's retinopathy
pyramidal d. buttress foot
quiet hip d. Legg-Calvé-Perthes d
Quincke's d. angioedema
rabbit hemorrhagic d. a highly infectious d. of rabbits, caused by a calicivirus and characterized by hemorrhagic lesions, particularly affecting the lungs and liver; since it was first identified in China in 1984, it has been reported from Korea, it has spread through Europe, and it has reached North Africa and Mexico.
ragpicker's d. pulmonary anthrax
ragsorter's d. , rag-sorter's d. pulmonary anthrax
rag-sorter's d.
railroad d. transport tetany
Ranikhet d. Newcastle d [Ranikhet, town in northern India]
rat-bite d. rat-bite fever
Raussly d. a rare autosomal dominant neurological disorder with many of the clinical features of hereditary hypertrophic sensorimotor polyneuropathy combined with an essential tremor.hereditary areflexic dystasia;
Rayer's d. biliary xanthomatosis
Raynaud's d. Raynaud's syndrome
Recklinghausen's d. of bone osteitis fibrosa cystica
Recklinghausen's d. type I type 2 neurofibromatosis. See neurofibromatosis.
Refsum's d. [MIM*266500] a rare degenerative disorder transmitted as an autosomal recessive trait and caused by the absence of phytanic acid a-hydroxylase; clinically characterized by retinitis pigmentosa, demyelinating polyneuropathy, deafness, nystagmus, and cerebellar signs; infantile Refsum's d. [MIM *266510] is an impaired peroxisomal function with accumulation of phytanic acid, pipecolic acid, etc; autosomal recessive inheritance.heredopathia atactica polyneuritiformis, Refsum's syndrome;
Reiter's d. Reiter's syndrome
reportable d. >notifiable d
rhesus d. sensitization of the mother during pregnancy to Rh factor in fetal blood, leading to erythroblastosis fetalis.
rheumatic d. See rheumatism.
rheumatic heart d. d. of the heart resulting from rheumatic fever, chiefly manifested by abnormalities of the valves.
rheumatoid d. rheumatoid arthritis, referring particularly to nonarticular lesions such as subcutaneous nodules.
Ribas-Torres d. a mild form of smallpox. See also variola minor.
rice d. beriberi, the original outbreaks of which were caused by feeding people rice from which the husks had been removed (polished rice), decreasing the vitamin B1 content of the rice.
Riedel's d. Riedel's thyroiditis
Riga-Fede d. ulceration of the lingual frenum in teething infants, related to abrasion of the tissue against the new central incisors.
Robinson's d. ohbsolete term for hidrocystoma(s) occurring in the skin of the face, especially in the region of the eyes.
Roger's d. a congenital cardiac anomaly consisting of a small, isolated, asymptomatic defect of the interventricular septum.maladie de Roger;
Rokitansky's d. 1. acute yellow atrophy of the liver 2. Chiari's syndrome
Romberg's d. facial hemiatrophy
Rosai-Dorman d. sinus histiocytosis with massive lymphadenopathy
Rosenbach's d. 1. Heberden's nodes, under node 2. erysipeloid
Roth-Bernhardt d. meralgia paraesthetica
Roth's d. meralgia paraesthetica
Rougnon-Heberden d. angina pectoris
round heart d. a spontaneous cardiomyopathy of unknown etiology that affects young turkeys; characterized by sudden death due to cardiac arrest.
Roussy-Lévy d. [MIM*180800] a type of cerebellar ataxia regularly associated with wasting of the calves and intrinsic muscles of the hands and with absent tendon reflexes; pes cavus and claw toes develop; autosomal dominant inheritance.Roussy-Lévy syndrome;
Rubarth's d. infectious canine hepatitis
runt d. a graft versus host reaction in mice first observed following intravenous injection of allogeneic spleen cells into newborn animals.wasting d;
Rust's d. tuberculosis of the two upper cervical vertebrae and their articulations.malum vertebrale suboccipitale, spondylarthrocace (2) , spondylocace (2);
salivary gland d. disorder of salivary glands; i.e., Sjögren's syndrome.
salivary gland virus d. See cytomegalic inclusion d.
Salla d. (sal´ya) an autosomal recessive disorder in which there is a defect in the transport of free sialic acid across lysosomal membranes.
salmon d. salmon poisoning
Sandhoff's d. [MIM*268800] an infantile form of GM2 gangliosidosis characterized by a defect in the production of hexosaminidases A and B; it resembles Tay-Sachs disease, but occurs predominantly (if not entirely) in non-Jewish children; accumulation of glucoside and ganglioside Gm2.
sandworm d. an inflammatory eruption on the inner side of the sole, observed in certain parts of Australia, marked by a patch of erythema spreading in spirals, and disappearing spontaneously; probably a form of creeping eruption similar to larva migrans.
San Joaquin Valley d. primary coccidioidomycosis
Schenck's d. sporotrichosis
Scheuermann's d. epiphysial aseptic necrosis of vertebral bodies.adolescent round back, juvenile kyphosis, osteochondritis deformans juvenilis dorsi;
Schilder's d. term used to describe at least two separate disorders described by Schilder: 1) Diffuse sclerosis or encephalitis periaxialis diffusa; a nonfamilial disorder affecting primarily children and young adults and characterized by progressive dementia, visual disturbances, deafness, pseudobulbar palsy, and hemiplegia or quadriplegia. Most patients die within a few years of onset; pathologically, there is a large, asymmetrical area of myelin destruction, sometimes involving an entire cerebral hemisphere, and typically with extension across the corpus callosum. 2) The leukodystrophies.encephalitis periaxialis diffusa, Flatau-Schilder d;
Schindler d. (shind´ler) an autosomal recessive disorder with deficient activity of a-N-acetylgalactosaminidase resulting in accumulation of glycoproteins and other substrates which are deposited in terminal axons, primarily in gray matter.
Schlatter's d. , Schlatter-Osgood d. Osgood-Schlatter d
Scholz' d. former eponym for the juvenile form of metachromatic leukodystrophy.
Schönlein's d. Henoch-Schönlein purpura
Schottmueller's d. paratyphoid fever
Schüller's d. Hand-Schüller-Christian d
sclerocystic d. of the ovary polycystic ovary syndrome
sea-blue histiocyte d. [MIM*269600] splenomegaly and mild thrombocytopenia, with histiocytes in the bone marrow which contain cytoplasmic granules that stain bright blue; sometimes familial; perhaps a lipidosis; autosomal recessive inheritance.
secondary d. 1. a d. that follows and results from an earlier disease, injury, or event; 2. a wasting disorder that follows successful transplantation of bone marrow into a lethally irradiated host; frequently severe and usually associated with fever, anorexia, diarrhea, dermatitis, and desquamation. See also graft versus host d.
self-limited d. a d. process that resolves spontaneously with or without specific treatment.
Senear-Usher d. pemphigus erythematosus
senile hip d. malum coxae senile
serum d. serum sickness
sexually transmitted d. (STD) See venereal disease.
Shaver's d. bauxite pneumoconiosis
shimamushi d. (she-ma-mu´she) tsutsugamushi d
sickle cell d. sickle cell anemia
sickle cell C d. [MIM*141900] a d. resulting from abnormal sickle-shaped erythrocytes (containing hemoglobin C and S) which appear in response to a lowering of the partial pressure of oxygen; characterized by anemia, crises due to hemolysis or vascular occlusion, chronic leg ulcers and bone deformities, and infarcts of bone or of the spleen.
sickle cell-thalassemia d. microdrepanocytic anemia
silo-filler's d. a pulmonary lesion produced by oxides of nitrogen due to fresh silage; in its acute form it may lead to death from pulmonary edema or may go on to a subacute or chronic proliferative pulmonary disease sometimes leading to chronic pulmonary invalidism.
Simmonds' d. anterior pituitary insufficiency due to trauma, vascular lesions, or tumors; usually developing postpartum as a result of pituitary necrosis caused by ischemia during a hypotensive episode during delivery; characterized clinically by asthenia, loss of weight and body hair, arterial hypotension, and manifestations of thyroid, adrenal, and gonadal hypofunction.hypophysial cachexia, pituitary cachexia;
Simons' d. progressive lipodystrophy
sixth d. exanthema subitum
sixth venereal d. venereal lymphogranuloma
Sjögren's d. Sjögren's syndrome
skinbound d. scleroderma (usually applied to extensive involvement).
slipped tendon d. a manganese-deficiency perosis in the young chick, which allows the tendons on the caudal aspect of the tarsus to displace medially and laterally, so that the chick squats and walks on the plantar surface of the limbs.
slow virus d. a d. that follows a slow, progressive course spanning months to years, frequently involving the central nervous system, and ultimately leading to death, such as visna and maedi of sheep, caused by viruses of the subfamily Lentivirinae (family Retroviridae), and subacute sclerosing panencephalitis, seemingly caused by the measles virus; spongiform encephalopathies including kuru of man, scrapie of sheep, and transmissible encephalopathy of mink may also be classified under slow virus d. but their respective etiologic agents have not been adequately characterized.
Sneddon-Wilkinson d. subcorneal pustular dermatosis
social d.'s obsolete term used to designate venereal d.'s, especially gonorrhea and syphilis.
specific d. a d. produced by the action of a special pathogenic microorganism.
Spielmeyer-Sjögren d. cerebral sphingolipidosis, late juvenile type.
Spielmeyer-Stock d. retinal atrophy in amaurotic familial idiocy.
Spielmeyer-Vogt d. cerebral sphingolipidosis, late juvenile type.Vogt-Spielmeyer d;
Stargardt's d. [MIM*248200] fundus flavimaculatus initiated with atrophic macular lesions.
Steele-Richardson-Olszewski d. progressive supranuclear palsy
Steinert's d. myotonic dystrophy
Sticker's d. erythema infectiosum
stiff lamb d. a muscular dystrophy occurring in young lambs fed on ewe's milk or on feed that is deficient in vitamin E or selenium, or both. See also white muscle d.
Still's d. a form of juvenile chronic arthritis (formerly juvenile rheumatoid arthritis) characterized by high fever and signs of systemic illness that can exist for months before the onset of arthritis.
Stokes-Adams d. Adams-Stokes syndrome
stone-mason's d. silicosis
storage d. a generic term that includes any accumulation of a specific substance within tissues, generally because of congenital deficiency of an enzyme necessary for further metabolism of the substance; e.g., glycogen-storage d.'s.
Strümpell-Marie d. ankylosing spondylitis
Strümpell's d. 1. spondylitis deformans 2. acute epidemic leukoencephalitis
Strümpell-Westphal d. Wilson's d. (1)
Sturge-Weber d. Sturge-Weber syndrome
Stuttgart d. the uremic form of canine leptospirosis.canine typhus;
Sulzberger-Garbe d. d. resembling an exudative form of nummular eczema described in Jewish males with oval lesions on the penis, trunk, and face.exudative discoid and lichenoid dermatitis, Sulzberger-Garbe syndrome;
Sutton's d. 1. halo nevus [R. L. Sutton] 2. aphthae major, under aphtha [R. L. Sutton, Jr.]
Swediauer's d. Albert's d
sweet clover d. a hemorrhagic d., due to dicumarol which causes marked reduction in prothrombin, occurring in cattle fed on sweet clover fodder, spoiled during curing.
Sweet's d. acute febrile neutrophilic dermatosis
Swift's d. acrodynia (2)
swineherd's d. a leptospirosis caused by a leptospira occurring in those who attend swine or who are occupied in the slaughtering or processing of pork, and characterized by aches and pains throughout the body, fever, headache, dizziness, and nausea.
swine vesicular d. a contagious disease of swine caused by a porcine enterovirus of the family Picornaviridae, closely related to the human enterovirus Coxsackie B-5, and characterized by vesicular lesions and erosions of the epithelium of the mouth, nares, snout, and feet; human infections have been reported in laboratory workers.
swollen belly d. a fatal d. of infants infected with Strongyloides fuelleborni subsp. kellyi; appears in localized areas of New Guinea.swollen belly syndrome;
Sydenham's d. Sydenham's chorea
Sylvest's d. epidemic pleurodynia
systemic autoimmune d.'s a group of connective tissue d.'s characterized by the presence of autoantibodies responsible for immunopathologically mediated tissue lesions; systemic lupus erythematosus is the prototype.
systemic febrile d.'s generic term for diseases characterized by fever.
Takahara's d. acatalasia
Takayasu's d. Takayasu's arteritis
Tangier d. analphalipoproteinemia [an island in the Chesapeake Bay, home of the family of first cases described]
Taussig-Bing d. Taussig-Bing syndrome
Taylor's d. diffuse idiopathic cutaneous atrophy.
Tay-Sachs d. a lysosomal storage disease, resulting from hexosaminidase A deficiency. The monosialoganglioside is stored in central and peripheral neuronal cells. Infants present with hyperacusis and irritability, hypotonia, and failure to develop motor skills. Blindness with macular cherry red spots and seizures are evident in the first year. Death occurs within a few years. Autosomal-recessive transmission; found primarily in Jewish populations.infantile GM2 gangliosidosis;
Teschen d. porcine polioencephalomyelitis; a d. of swine caused by porcine enterovirus 1 and resembling human poliomyelitis; it is characterized by stiffness, convulsions, paralysis, and prostration, and is widespread in Europe, with most serious losses occurring in Poland and the Czech Republic and Slóvakia.infectious porcine encephalomyelitis, porcine polioencephalomyelitis; [Teschen, Silisia]
Theiler's d. 1. mouse encephalomyelitis 2. equine serum hepatitis
Thiemann's d. Thiemann's syndrome
third d. rubella
Thomsen's d. myotonia congenita
Thygeson's d. superficial punctate keratitis
thyrocardiac d. heart d. resulting from hyperthyroidism.
thyrotoxic heart d. cardiac symptoms, signs, and physiologic impairment due to overactivity of the thyroid gland usually due to excessive sympathetic stimulation.
Tommaselli's d. hemoglobinuria and pyrexia due to quinine intoxication.
Tornwaldt's d. inflammation or obstruction of the pharyngeal bursa or an adenoid cleft with the formation of a cyst containing pus.
torsion d. of childhood dystonia musculorum deformans
Tourette's d. Tourette syndrome
Trevor's d. tarsoepiphyseal aclasis
tropical d.'s infectious and parasitic d.'s endemic in tropical and subtropical zones, including Chagas' disease, leishmaniasis, leprosy, malaria, onchocerciasis, schistosomiasis, sleeping sickness, yellow fever, and others; often water- or insect-borne. See also emerging viruses, under virus.
tsutsugamushi d. (su´su-ga-mu´she) an acute infectious disease, caused by Rickettsia tsutsugamushi and transmitted by Trombicula akamushi and T. deliensis, that occurs in harvesters of hemp in some parts of Japan; characterized by fever, painful swelling of the lymphatic glands, a small blackish scab on the genitals, neck, or axilla, and an eruption of large dark red papules.akamushi d., flood fever, inundation fever, island d., island fever, Japanese river fever, kedani fever, mite typhus, scrub typhus, shimamushi d., tropical typhus, tsutsugamushi fever;
tunnel d. ancylostomiasis
Tyzzer's d. an acute d. of many animal species (especially laboratory animals such as mice and rabbits) caused by the bacterium Bacillus piliformis and characterized by depression, diarrhea, and sudden death.
Underwood's d. sclerema neonatorum
Unna's d. seborrheic dermatitis
Unverricht's d. [MIM*254800] a progressive myoclonic epilepsy; one of the degenerative gray matter disorders characterized by myoclonus and generalized seizures, with progressive neurological and intellectual decline; age of onset between 8 and 13 years of age; autosomal recessive inheritance.
Urbach-Wiethe d. lipoid proteinosis
vagabond's d. parasitic melanoderma
vagrant's d. parasitic melanoderma
van Buren's d. Peyronie's d
Vaquez' d. polycythemia vera
veldt d. heartwater
venereal d. any contagious d. acquired during sexual contact; e.g., syphilis, gonorrhea, chancroid.
veno-occlusive d. of the liver obliterating endophlebitis of small hepatic vein radicles, described in Jamaican children, associated with ingestion of toxic plant substances in bush tea; causes ascites, which may progress to cirrhosis.
Vidal's d. obsolete term for lichen simplex chronicus.
Vincent's d. necrotizing ulcerative gingivitis
Virchow's d. megacephaly
virus X d. a term applied to a number of virus d.'s of obscure etiology, e.g., Australian X d. (Murray Valley encephalitis).
Vogt-Spielmeyer d. Spielmeyer-Vogt d
Voltolini's d. d. of the labyrinth, leading to deafmutism, in young children.
von Economo's d. A unique encephalitis, presumably viral in origin, which followed the influenza pandemic of 1914-1918. Symptoms included ophthalmoplegia and marked somnolence, and in many survivors, the delayed development of Parkinson's disease; the basis for postencephalitic Parkinsonism.encephalitis lethargica, polioencephalitis infectiva;
von Gierke's d. type 1 glycogenosis
von Meyenburg's d. relapsing polychondritis
von Recklinghausen d. type 1 neurofibromatosis. See neurofibromatosis.
von Willebrand's d. [MIM*193400] a hemorrhagic diathesis characterized by tendency to bleed primarily from mucous membranes, prolonged bleeding time, normal platelet count, normal clot retraction, partial and variable deficiency of factor VIIIR, and possibly a morphologic defect of platelets; autosomal dominant inheritance with reduced penetrance and variable expressivity. Type III von Willebrand's d. is a more severe disorder with markedly reduced factor VIIIR levels. There is a recessive version of this disease [MIM*277480] which has the remarkable property that it represents a mutation at the same locus as the undominant form.
Voorhoeve's d. osteopathia striata
Wagner's d. hyaloideoretinal degeneration
Wardrop's d. onychia maligna
wasting d. runt d
Weber-Christian d. relapsing febrile nodular nonsuppurative panniculitis
Wegner's d. syphilitic osteochondritis
Weil's d. A form of leptospirosis generally caused by Leptospira interrogans serogroup icterohaemorrhagiae, believed to be acquired by contact with the urine of infected rats; characterized clinically by fever, jaundice, muscular pains, conjunctival congestion, and albuminuria; agglutinins regularly appear in the serum.infectious icterus, infectious jaundice (1) , Larrey-Weil d;
Weir Mitchell's d. erythromelalgia
Werdnig-Hoffmann d. infantile spinal muscular atrophy
Werlhof's d. obsolete term for idiopathic thrombocytopenic purpura.
Wernicke's d. Wernicke's syndrome
Werther's d. dermatitis nodularis necrotica
Wesselsbron d. Wesselsbron fever
Westphal's d. Wilson's d. (1)
Whipple's d. a rare d. characterized by steatorrhea, frequently generalized lymphadenopathy, arthritis, fever, and cough; many "foamy" macrophages are found in the jejunal lamina propria; lymph nodes contain periodic acid-Schiff positive particles that appear bacilliform by electron microscopy.
white muscle d. a nutritional myopathy of young animals, manifested by stiffness and soreness; cardiac muscle damage is frequent, and affected muscles exhibit whitish, chalklike streaks, which are degenerated fibers; it is due to a deficiency of vitamin E or selenium, or both, and is seen most frequently in calves and lambs but has also been reported in other species.
white spot d. morphea guttata
Whitmore's d. melioidosis
Wilkie's d. superior mesenteric artery syndrome
Wilson's d. 1. disorder characterized by cirrhosis, d. in the basal ganglia of the brain, and deposition of green pigment in the periphery of the cornea; the plasma levels of ceruloplasmin and copper are decreased, urinary excretion of copper is increased, and the amounts of copper in the liver, brain, kidneys, and lenticular nucleus are unusually high, while cytochrome oxidase is reduced; autosomal recessive inheritance;hepatolenticular degeneration (2) , hepatolenticular d., lenticular progressive degeneration, pseudosclerosis (2) , Strümpell-Westphal d., Westphal's d., Westphal's pseudosclerosis, Westphal-Strümpell pseudosclerosis, Wilson's syndrome; See also Kayser-Fleischer ring. [S. A. K. Wilson] 2. exfoliative dermatitis [Sir W.J.E. Wilson]
Winiwarter-Buerger d. thromboangiitis obliterans
Winkler's d. chondrodermatitis nodularis chronica helicis
Wohlfart-Kugelberg-Welander d. juvenile spinal muscular atrophy
Wolman's d. See cholesterol ester storage d. Cf. cholesterol ester storage d.
woolsorter's d. , wool-sorter's d. pulmonary anthrax
Woringer-Kolopp d. a benign localized form of lymphoma with solitary or closely grouped cutaneous tumors consisting of predominantly epidermal infiltration of mononuclear cells resembling those found in mycosis fungoides.pagetoid reticulosis;
X d. one of several viral d.'s of obscure etiology.
X d. of cattle bovine hyperkeratosis
yellow d. xanthochromia
Ziehen-Oppenheim d. dystonia musculorum deformans


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