Physicians Desk Reference Physicians Desk Reference
Browsable database of medical products, manufacturer, therapeutic categories, indication, contra indication, side effects, drug and food interaction.
Medical Product | Medical Manufacturer | Therapheutic | Indication | Contra Indication | Side Effect | Drug Interaction | Food Interaction

inhibitor

inhibitor (in-hib´i-ter, -tor)

1. An agent that restrains or retards physiologic, chemical, or enzymatic action. 2. A nerve, stimulation of which represses activity. See also inhibition.
angiotensin-converting enzyme i.'s (ACEI) a class of drugs used in the treatment of hypertension; they produce a reduction of peripheral arterial resistance, although the exact mechanism of action has not been fully determined; they block the conversion of angiotensin I to angiotensin II, a powerful vasoconstrictor.
aromatase i.'s drugs, such as aminoglutethimide, that inhibit aromatase, an enzyme used in the synthesis of estrogens.
Bowman-Birk i. a polypeptide that will inhibit both trypsin and chymotrypsin.
carbonate dehydratase i. an agent, usually chemically related to the sulfonamides, that inhibits the activity of carbonate dehydratase, producing a general decrease in the formation of H2CO3 in the tissues. See also acetazolamide, dichlorphenamide.carbonic anhydrase i;
carbonic anhydrase i. carbonate dehydratase i
C1 esterase i. an a2-neuraminoglycoprotein that inhibits the enzymatic activity of C1 esterase, the activated first component of complement. A deficiency of this i. results in a lack of inhibition of C1r and C1s leading to uncontrolled activation of the complement cascade and edema.
cholinesterase i. a drug, such as neostigmine, which, by inhibiting biodegradation of acetylcholine, restores myoneural function in myasthenia gravis or after nondepolarizing neuromuscular relaxants have been administered.
familial lipoprotein lipase i. an i. found in certain individuals that inhibits lipoprotein lipase resulting in accumulation of chylomicrons, VLDL, and triacylglycerols; similar in symptoms to familial lipoprotein lipase deficiency.
glucosidase i.'s agents such as acarbose which reduce gastrointestinal absorption of carbohydrates. This group of drugs has been known popularly as "starch blockers". They lower plasma glucose levels and tend to cause weight loss. A limiting side effect is flatulence.
HMG CoA reductase i.'s drugs, such as lovastatin and pravastatin, which interfere with the biosynthesis of cholesterol; used to treat hyperlipidemia.
human a1-proteinase i. (a1PI) a1-antitrypsin
beta-lactamase i.'s drugs such as clavulanic acid, which are used to inhibit bacterial beta-lactamases; often used with a penicillin or cephalosporin to overcome drug resistance.
lipoprotein-associated coagulation i. (LACI) formerly known as anticonvertin; a protein that inhibits the extrinsic pathway of coagulation by binding to the tissue factor III-factor VII-Ca2+-factor Xa complex.
mechanism-based i. suicide substrate
monoamine oxidase i. (MAOI) any of the hydrazine (-NHNH2) and hydrazide (-CONHNH2) derivatives that inhibit several enzymes and raise the brain norepinephrine and 5-hydroxytryptamine levels; used as antidepressant and hypotensive agents.
ovulation i. a compound that inhibits ovulation; often found in oral contraceptives.
residual i. a sound-generating device, worn in the ear, which inhibits or suppresses the sounds of tinnitus by masking, with a residual inhibitory effect when the device is turned off.
respiratory i. a compound that inhibits the respiratory chain.respiratory poison;
serine protease i.'s a class of highly polymorphic inhibitors of trypsin, elastase, and certain other proteases synthesized by hepatocytes and macrophages See also a1-antitrypsin.serpins;
trypsin i. 1. a peptide hydrolyzed off trypsinogen under the catalytic influence of enteropeptidase, with trypsin produced as a result; so called because the peptide masks or inhibits the active site of the trypsin molecule; 2. one of the polypeptides, from various sources (e.g., human and bovine colostrum, soybeans, egg white), that inhibit the action of trypsin. Cf. Bowman-Birk i.
a1-trypsin i. a1-antitrypsin

 

Browse Medical References:

[A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M]
[N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]