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1. A representation of something, often idealized or modified to make it conceptually easier to understand. 2. Something to be imitated. 3. In dentistry, a cast. [It. midello, fr. L. modus, measure, standard]
Adair-Koshland-Némethy-Filmer m. (AKNF) Koshland-Némethy-Filmer m See Koshland-Némethy-Filmer m.
additive m. a m. in which the combined effect of several factors is the sum of the effects that would be produced by each of the factors in the absence of the others.
animal m. study in a population of laboratory animals that uses conditions of animals analogous to conditions of humans to simulate processes comparable to those that occur in human populations.
Bingham m. a m. representing the flow behavior of a Bingham plastic, in the idealized case.
biomedical m. a conceptual m. of illness that excludes psychological and social factors and includes only biological factors in an attempt to understand a person's medical illness or disorder.
biopsychosocial m. a conceptual m. that assumes that psychological and social factors must also be included along with the biological in understanding a person's medical illness or disorder.
cloverleaf m. a m. for the structure of tRNA; so named because the structure roughly resembles a cloverleaf.
computer m. a mathematical representation of the functioning of a system, presented in the form of a computer program.computer simulation;
concerted m. Monod-Wyman-Changeux m
cooperativity m. a m. used to explain the property of cooperativity observed in certain enzymes; e.g., allosterism or hysteresis.
fluid mosaic m. a m. for the structure of a biomembrane, with lateral diffusibility of constituents and little, if any, flip-flop motion.
genetic m. a formalized conjecture about the behavior of a heritable structure in which the component terms are intended to have literal interpretation as standard structures of empirical genetics.
induced fit m. 1. a m. to suggest a mode of action of enzymes in which the substrate binds to the active site of the protein, causing a conformational change in the protein; 2. Koshland-Némethy-Filmer m
Koshland-Némethy-Filmer m. (KNF model) a m. to explain the allosteric form of cooperativity; in this m., in the absence of ligands, the protein exists in only one conformation; upon binding, the ligand induces a conformational change that may be transmitted to other subunits.Adair-Koshland-Némethy-Filmer m., induced fit m. (2);
lock-and-key m. a m. used to suggest the mode of operation of an enzyme in which the substrate fits into the active site of the protein like a key into a lock.
logistic m. a statistical m.; in epidemiology, a m. of risk as a function of exposure to a risk factor.
mathematical m. representation of a system, process, or relationship in mathematical form, using equations to simulate the behavior of the system or process under study.
medical m. a set of assumptions that views behavioral abnormalities in the same framework as physical disease or abnormalities.
Monod-Wyman-Changeux m. (MWC m.) a m. used to explain the allosteric form of cooperativity; in this m., an oligomeric protein can exist in two conformational states in the absence of the ligand; these states are in equilibrium and the one that is predominant has a lower affinity for the ligand (which binds to the protein in a rapid equilibrium fashion).concerted m;
multiplicative m. a m. in which the joint effect of two or more causes is the product of their effects if they were acting alone.
multistage m. a mathematical m., mainly for carcinogenesis, based on the theory that a specific carcinogen may affect one among a number of stages in the development of cancer.
MWC m. abbreviation for Monod-Wyman-Changeux m.
pathological m. an animal or animal stock that by inheritance or by artificial manipulation develops a disorder similar to some disease of interest and hence directly or by analogy furnishes evidence of its pathogenesis and may be used as a m. for the study of preventive or therapeutic measures.
statistical m. a formal representation for a class of processes that allows a means of analyzing results from experimental studies, such as the Poisson m. or the general linear m.; it need not propose a process literally interpretable in the context of the individual case.
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