quinacrine hydrochloride

quinacrine hydrochloride (kwin´a-kren, -krin)

An acridine derivative, C23H30ClN3O. 2HCl. 2H2O, used as an antimalarial that destroys the trophozoites of Plasmodium vivax and P. falciparum, but does not affect the gametocytes, sporozoites, or exoerythrocytic stage of parasites; also used as an anthelmintic. As a dihydrochloride, it is used as a stain in cytogenetics to demonstrate Y chromatin by fluorescent microscopy. Q.h. intercalates with DNA and also uncouples oxidative and photophosphorylation.atebrine hydrochloride, mepacrine hydrochloride;

 

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