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sclerosis, pl. scleroses (skle-ro´sis, -sez)
1. induration (2) 2. In neuropathy, induration of nervous and other structures by a hyperplasia of the interstitial fibrous or glial connective tissue. [G. sklerosis, hardness]
Alzheimer's s.hyaline degeneration of the medium and smaller blood vessels of the brain.
amyotrophic lateral s. (ALS) a disease of the motor tracts of the lateral columns and anterior horns of the spinal cord, causing progressive muscular atrophy, increased reflexes, fibrillary twitching, and spastic irritability of muscles; associated with a defect in superoxide dismutase. A number of cases are inherited as an autosomal dominant trait [MIM*105400]. This disorder affects adults, is 90-95% sporadic in nature, and is usually fatal within 2 to 4 years of onset. Variants include progressive spinal muscle atrophy, in which only a lower motor neuron component occurs, and progressive bulbar palsy, in which isolated or predominantly lower brainstem motor involvement is seen.Aran-Duchenne disease, Charcot's disease, creeping palsy, Cruveilhier's disease, Duchenne-Aran disease, Lou Gehrig's disease, muscular trophoneurosis, progressive muscular atrophy, progressive spinal amyotrophy, wasting palsy, wasting paralysis;
arteriocapillary s.arteriosclerosis, especially of the finer vessels.
Canavan's s.Canavan's disease
central areolar choroidal s.areolar choroidopathy
combined s.subacute combined degeneration of the spinal cord
diffuse infantile familial s.globoid cell leukodystrophy
disseminated s.multiple s
endocardial s. 1. endocardial fibroelastosis (1) 2. endocardial fibrosis
focal s.multiple s
hippocampal s.a loss of cortical neurons and a reactive astrocytosis in the hippocampal regions of some persons with epilepsy.
idiopathic hypercalcemic s. of infants See idiopathic hypercalcemia of infants.
insular s.multiple s
laminar cortical s.a degeneration of nerve fibers in the corona radiata in a laminar pattern.
lateral spinal s.primary lateral s
lobar s.Pick's atrophy
mantle s.a common cerebral lesion in the palsied states of early life characterized by nodular cortical atrophy.
menstrual s.physiologic s
Mönckeberg's s.Mönckeberg's arteriosclerosis
multiple s. (MS) common demyelinating disorder of the central nervous system, causing patches of sclerosis (plaques) in the brain and spinal cord; occurs primarily in young adults, and has protean clinical manifestations, depending upon the location and size of the plaque; typical symptoms include visual loss, diplopia, nystagmus, dysarthria, weakness, paresthesias, bladder abnormalities, and mood alterations; characteristically, the plaques are "separated in time and space" and clinically the symptoms show exacerbations and remissions.disseminated s., focal s., insular s;
nuclear s.increased refractivity of the central portion of the lens of the eye. See nuclear cataract.
ovulational s.physiologic s
physiologic s.a slowly progressive s. in the walls of the ovarian arteries which commences after puberty.menstrual s., ovulational s;
posterior s.tabetic neurosyphilis
posterior spinal s.tabetic neurosyphilis
primary lateral s.considered by many to be a subgroup of motor neuron disease; a slowly progressive degenerative disorder of the motor neurons of the cerebral cortex, resulting in widespread weakness on an upper motor neuron basis; spasticity, hyperreflexia, and Babinski signs are present, but not fasciculation potentials, nor any electrodiagnostic evidence of a lower motor neuron lesion.lateral spinal s;
systemic s.a systemic disease characterized by formation of hyalinized and thickened collagenous fibrous tissue, with thickening of the skin and adhesion to underlying tissues (especially of the hands and face), dysphagia due to loss of peristalsis and submucosal fibrosis of the esophagus, dyspnea due to pulmonary fibrosis, myocardial fibrosis, and renal vascular changes resembling those of malignant hypertension; Raynaud's phenomenon, atrophy of the soft tissues, and osteoporosis of the distal phalanges (acrosclerosis), sometimes with gangrene at the ends of the digits, are common findings. The term progressive systemic s. is commonly used and is appropriate for cases with initially widespread skin involvement including the trunk. However, when skin involvement is limited to the distal extremities and face there is often prolonged delay in appearance of visceral manifestations.
tuberous s. [MIM*191100] phacomatosis characterized by the formation of multisystem hamartomas producing seizures, mental retardation, and skin nodules of the face, originally considered to be sebaceous adenomas but since shown to be angiofibromas; the cerebral and retinal lesions are glial nodules; other skin lesions are white macules, shagreen patches, and periungual fibromas; autosomal dominant inheritance with variable expression.Bourneville's disease, epiloia;
unicellular s.a growth of fibrous tissue between and isolating the individual cells of a part.
valvular s.fibrosis, often with calcification of valves, considered to be an aging change and not due to primary valvular disease.
s. of white matterleukodystrophy
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