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syphilis (sif´i-lis)

An acute and chronic infectious disease caused by Treponema pallidum and transmitted by direct contact, usually through sexual intercourse. After an incubation period of 12 to 30 days, the first symptom is a chancre, followed by slight fever and other constitutional symptoms (primary s.), followed by a skin eruption of various appearances with mucous patches and generalized lymphadenopathy (secondary s.), and subsequently by the formation of gummas, cellular infiltration, and functional abnormalities usually resulting from cardiovascular and central nervous system lesions (tertiary s.).lues venerea, malum venereum; [Mod. L. syphilis (syphilid-), (?) fr. a poem, Syphilis sive Morbus Gallicus, by Fracastorius, Syphilus being a shepherd and principal char.]
cardiovascular s.involvement of the cardiovascular system seen in late s., usually resulting in aortitis, aneurysm formation, and aortic valvular insufficiency.
congenital s.s. acquired by the fetus in utero, thus present at birth.hereditary s., s. hereditaria;
s. d'emblée (dom-bla´) s. occurring without an initial sore. [Fr. right away]
early s.primary, secondary, or early latent s., before any tertiary manifestations have appeared.
early latent s.infection with Treponema pallidum, the organism of syphilis, after the primary and secondary phases have subsided, during the first year after infection, before any manifestations of tertiary syphilis have appeared.
endemic s.nonvenereal s
equine s.dourine
s. heredita´riacongenital s
hereditary s.congenital s
s. heredita´ria tar´das., believed to be congenital, but not manifesting itself until several years after birth.
late s.involvement of the cardiovascular or central nervous system, or the development of a gumma in any organ, due to infection with Treponema pallidum; usually several years to 2-3 decades after the initial infection.tertiary s;
late benign s.late s., manifested by serologic evidence of infection, but without any clinical manifestations.
late latent s.Usually infectious in pregnant women only, who may pass the infection on to the fetus.
latent s.infection with Treponema pallidum, after the manifestations of primary and secondary s. have subsided (or were never noticed), before any manifestations of tertiary s. have appeared.
meningovascular s.a rare manifestation of secondary or tertiary s. characterized by mild, nonsuppurative, chronic inflammation of the leptomeninges and an intracranial or spinal angiitis.
nonvenereal s.s. caused by organisms closely related to Treponema pallidum; spread by personal, but not necessarily venereal, contact; usually acquired in childhood, most common in areas of provery and overcrowding; rare in the United States; includes yaws, pinta and bejel.endemic s;
primary s.the first stage of s. See syphilis.
quaternary s.parasyphilis
secondary s.the second stage of s. See syphilis.mesosyphilis;
tertiary s.late s


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