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cooperativity

cooperativity

A property of certain proteins (often enzymes) in which the bind curves or saturation curves or, in the case of enzyme, a plot of initial rates as a function of initial substrate concentration, are nonhyperbolic; suggests that the binding of a ligand has a different affinity at different ligand concentrations. Both allosterism and hysteresis are models that will display c. Cf. allosterism, hysteresis.
negative c. c. in which successive ligand molecules appear to bind with decreasing affinity.
positive c. c. in which successive ligand molecules appear to bind with increasing affinity.

 

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